1. Genome-Scale Methods Converge on Key Mitochondrial Genes for the Survival of Human Cardiomyocytes in HypoxiaClinical Perspective
by Lindsay M. Edwards, Martin I. Sigurdsson, Peter A. Robbins, Michael E. Weale, Gianpiero L. Cavalleri, Hugh E. Montgomery, and Ines Thiele
Circ Genom Precis Med
Volume 7(4):
August 19, 2014
Copyright © American Heart Association, Inc. All rights reserved.

2. Heatmap showing the effect of hypoxia on flux distribution in the mitochondrial metabolic network.
Heatmap showing the effect of hypoxia on flux distribution in the mitochondrial metabolic network. Red=flux increased by >0.1 U; green=flux decreased by >0.1 U; yellow=flux changed by <0.1 U. A, Flux balance analysis, with ATP synthesis as the objective function. B, Uniform random sampling (U=μm min−1 g−1). TCA indicates tricarboxylic acid.
Lindsay M. Edwards et al. Circ Cardiovasc Genet. 2014;7:
Copyright © American Heart Association, Inc. All rights reserved.

3. Biplot showing scores on principal component (PC) 1 vs scores on principal component 2.
Biplot showing scores on principal component (PC) 1 vs scores on principal component 2. Both components are from a 5-component principal component analysis model of data sampled in hypoxia and normoxia. Black triangles=normoxia; gray stars=hypoxia.
Lindsay M. Edwards et al. Circ Cardiovasc Genet. 2014;7:
Copyright © American Heart Association, Inc. All rights reserved.