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Cardiopulmonary Interactions in PPHN

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Presentation on theme: "Cardiopulmonary Interactions in PPHN"— Presentation transcript:

1 Cardiopulmonary Interactions in PPHN
 PVR SVR  Pulmonary vasculature Heart Structural changes; altered reactivity to dilator and constrictor stimuli RV pressure overload and LV dysfunction Right-to-left shunting at PDA or FO Hypoxia, hypercarbia, acidosis Lung Lung volume  Compliance Intrapulmonary shunt Adapted from J Pediatr, vol. 126, Kinsella JP and Abman SH, Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn, pp , Copyright 1995, with permission from Elsevier.


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