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Cardiopulmonary Interactions in PPHN
PVR SVR Pulmonary vasculature Heart Structural changes; altered reactivity to dilator and constrictor stimuli RV pressure overload and LV dysfunction Right-to-left shunting at PDA or FO Hypoxia, hypercarbia, acidosis Lung Lung volume Compliance Intrapulmonary shunt Adapted from J Pediatr, vol. 126, Kinsella JP and Abman SH, Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn, pp , Copyright 1995, with permission from Elsevier.
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