1. Guanyu Wang gwang@gwu.edu 202-994-6482

2. Computational Biophysics
Network Modeling and Analysis
Hypoxia Response Network
Cell Cycle network
2. Computational Immunology
T cell competition and Immunodominance
HIV dynamics

3. Hypoxia Response Network
Collaborated with Drs. Zeng, Simha, Peng, Turano
FBA
Pathway switching explains HIF sharp response
FBA allows analytical solution of the network, instead of time consuming simulation

4. Cell Cycle Network Collaborated with Drs. Zeng, Simha
Network of 11 nodes
Network of 211 states
Figures cited from Li. PNAS 101:4781, 2004
A parameter to quantify robustness
Study how robustness is affected by degradation

5. T Cell Activation, Competition & Immunodominance
Collaborated with Yewdell (NIH) and Zeng
Different TCRs compete for antigen and APC spaces
Dramatic kinetic diversity during T cell activation
(different stages have different binding kinetics)

6. T Cell Activation, Competition & Immunodominance
Collaborated with Yewdell (NIH) and Zeng
koff
kon
Maturity structured modeling

7. HIV dynamics data simulation
Clinical data are from Pantaleo et al., N. Eng. J. Med., 328:327, 1993.