1. Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study
by Mirela Dobre, Wei Yang, Qiang Pan, Lawrence Appel, Keith Bellovich, Jing Chen, Harold Feldman, Michael J. Fischer, L. L. Ham, Thomas Hostetter, Bernard G. Jaar, Radhakrishna R. Kallem, Sylvia E. Rosas, Julia J. Scialla, Myles Wolf, Mahboob Rahman, and
J Am Heart Assoc
Volume 4(4):e001599
April 28, 2015
© 2015 Mirela Dobre et al.

2. Distribution of mean serum bicarbonate in CRIC participants over their course of participation in the study.
Distribution of mean serum bicarbonate in CRIC participants over their course of participation in the study. CRIC indicates Chronic Renal Insufficiency Cohort.
Mirela Dobre et al. J Am Heart Assoc 2015;4:e001599
© 2015 Mirela Dobre et al.

3. Percentage of follow‐up time spent with high, normal and low serum bicarbonate (N=3586 CRIC participants).
Percentage of follow‐up time spent with high, normal and low serum bicarbonate (N=3586 CRIC participants). CRIC indicates Chronic Renal Insufficiency Cohort.
Mirela Dobre et al. J Am Heart Assoc 2015;4:e001599
© 2015 Mirela Dobre et al.

4. Multivariable‐adjusted hazard ratios for time‐updated serum bicarbonate on heart failure (A) and renal events (B)* by subgroups in the CRIC Study using Marginal Structural Models.
Multivariable‐adjusted hazard ratios for time‐updated serum bicarbonate on heart failure (A) and renal events (B)* by subgroups in the CRIC Study using Marginal Structural Models. CRIC indicates Chronic Renal Insufficiency Cohort; eGFR, estimated glomerular filtration rate.
Mirela Dobre et al. J Am Heart Assoc 2015;4:e001599
© 2015 Mirela Dobre et al.