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Volume 65, Issue 1, Pages (January 2014)

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Presentation on theme: "Volume 65, Issue 1, Pages (January 2014)"— Presentation transcript:

1 Volume 65, Issue 1, Pages 99-112 (January 2014)
A Critical Analysis of the Role of Testosterone in Erectile Function: From Pathophysiology to Treatment—A Systematic Review  Andrea M. Isidori, Jacques Buvat, Giovanni Corona, Irwin Goldstein, Emmanule A. Jannini, Andrea Lenzi, Hartmut Porst, Andrea Salonia, Abdulmaged M. Traish, Mario Maggi  European Urology  Volume 65, Issue 1, Pages (January 2014) DOI: /j.eururo Copyright © 2013 European Association of Urology Terms and Conditions

2 Fig. 1 Causes of reduced androgen levels in men with erectile dysfunction. CNS=central nervous system. European Urology  , DOI: ( /j.eururo ) Copyright © 2013 European Association of Urology Terms and Conditions

3 Fig. 2 Sites of action of androgens in male sexual function. Blue arrows and dotted blue circles highlight the targets of testosterone. Ach=acetylcholine; Ca2+=calcium; cAMP=cyclic adenosine monophosphate; cGMP=cyclic guanosine monophosphate; eNOS=endothelial nitric oxide synthase; ET=endothelin; GC=guanylate cyclase; GTP=guanosine triphosphate; IP3=inositol triphosphate; K+=potassium; NANC=nonadrenergic-noncholinergic; NO=nitric oxide; PDE5=phosphodiesterase type 5; PGE=prostaglandin E; AC=adenylate cyclase; NE=norepinephrine; PLC=phospholipase C. European Urology  , DOI: ( /j.eururo ) Copyright © 2013 European Association of Urology Terms and Conditions

4 Fig. 3 Pathophysiology-oriented algorithm for the treatment of erectile dysfunction in men with altered circulating testosterone levels. ED=erectile dysfunction; hCG=human chorionic gonadotropin; LH=luteinizing hormone; PDE5-I=phosphodiesterase type 5 inhibitor; T=testosterone; TRT=testosterone replacement therapy. European Urology  , DOI: ( /j.eururo ) Copyright © 2013 European Association of Urology Terms and Conditions


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