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Volume 21, Issue 2, Pages (June 2014)

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1 Volume 21, Issue 2, Pages 169-175 (June 2014)
Short- and long-term treatment with folic acid suppresses thrombus formation in atherogenic mice in vivo  Yukinori Tamura, Ayumi Inoue, Yoshinobu Ijiri, Aki Naemura, Junichiro Yamamoto  Pathophysiology  Volume 21, Issue 2, Pages (June 2014) DOI: /j.pathophys Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Effects of short-term treatment with FA on the plasma folate levels (A) in young (age, 10 weeks) apoE−/−LDL−/− mice (0mg/kg: control [n=4], 20mg/kg [n=4]), and laser-induced thrombus formation (B) in young (n=9 in each group) and aged (age, 20 weeks, n=12 in each group) apoE−/−LDL−/− mice. Results are expressed as mean±SEM. *p<0.05, **p<0.01 vs. control group. mg/kg: mg/kg of FA administrated. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Effects of short-term treatment with FA on flow-mediated vasodilation (FMV) in vivo (A) and platelet reactivity ex vivo (B) in young (n=6 in each group) and aged (n=9 in each group) apoE−/−LDL−/− mice. Results are expressed as mean±SEM. *p<0.05 vs. control group. mg/kg: mg/kg of FA administrated. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Effects of long-term treatment with FA on plasma folate levels (A) and laser-induced thrombus formation (B) in apoE−/−LDL−/− mice fed with an atherogenic diet for 12 weeks. Results were expressed as mean±SEM. **p<0.01 vs. control group (n=9 in each group). mg/kg: mg/kg of FA administrated. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Effects of long-term treatment with FA on flow-mediated vasodilation (FMV; A), nitro-glycerine-mediated vasodilation (NMV; B) in vivo, and platelet reactivity ex vivo (C) in apoE−/−LDL−/− mice fed with an atherogenic diet for 12 weeks. Results were expressed as mean±SEM. *p<0.05, **p<0.01 vs. control group (n=9 in each group). mg/kg: mg/kg of FA administrated. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Effects of short-term (A) and long-term (B) treatment with FA on plasma homocysteine level in apoE−/−LDLR−/− mice. Results are expressed as mean±SEM. *p<0.05, **p<0.01 vs. control group (n=7 in each group). mg/kg: mg/kg of FA administrated. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions


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