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Refractory cutaneous lichenoid sarcoidosis treated with tranilast
Kyoko Nakahigashi, MD, Kenji Kabashima, MD, PhD, Hajime Akiyama, MD, Atsushi Utani, MD, PhD, Yoshiki Miyachi, MD, PhD Journal of the American Academy of Dermatology Volume 63, Issue 1, Pages (July 2010) DOI: /j.jaad Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 1 Clinical manifestations and histology. A, Widespread erythematous macules and plaques (the dark red lesion [asterisk] is a hemangioma simplex). B, Individual lesions were 3 to 5 mm in diameter, pinkish, follicular papules, as shown here on the abdomen. C, Confluent papules and erythematous plaques on the upper extremity. D, Histologic examination revealed a dermal granulomatous infiltrate including epithelioid cells without caseation necrosis. A few giant cells and a sparse lymphocytic infiltrate were noted. (Hematoxylin–eosin stain; original magnification: ×200.) Journal of the American Academy of Dermatology , DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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Fig 2 Clinical findings after oral tranilast therapy. After the treatment, the skin lesions on the abdomen (A) and on the upper extremity (B) were much improved. Journal of the American Academy of Dermatology , DOI: ( /j.jaad ) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions
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