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Predicting neurofibromatosis type 1 risk among children with isolated café-au- lait macules  Shay Ben-Shachar, MD, Tom Dubov, BSc, Hagit Toledano-Alhadef,

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Presentation on theme: "Predicting neurofibromatosis type 1 risk among children with isolated café-au- lait macules  Shay Ben-Shachar, MD, Tom Dubov, BSc, Hagit Toledano-Alhadef,"— Presentation transcript:

1 Predicting neurofibromatosis type 1 risk among children with isolated café-au- lait macules 
Shay Ben-Shachar, MD, Tom Dubov, BSc, Hagit Toledano-Alhadef, MD, Jacob Mashiah, MD, Eli Sprecher, MD, PhD, Shlomi Constantini, MD, MSc, Moshe Leshno, MD, PhD, Ludwine M. Messiaen, PhD  Journal of the American Academy of Dermatology  Volume 76, Issue 6, Pages e3 (June 2017) DOI: /j.jaad Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Decision tree for individuals with isolated café-au-lait macules (CALMs). The numbers in the tables represent the total number of individuals in the clinical and molecular cohorts along with the total number for each end point. NF1, Neurofibromatosis type 1. Journal of the American Academy of Dermatology  , e3DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Modified algorithm for detecting risk of neurofibromatosis 1 (NF1) among individuals with isolated café-au-lait macules (CALMs) based on clinical parameters. Journal of the American Academy of Dermatology  , e3DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

4 Supplemental Fig 1 Receiver operating characteristic curve of the training and testing groups of the molecular cohort and of the clinical (validation) cohort. The numbers represent the fraction of the area under the curve (AUC) for each category. Journal of the American Academy of Dermatology  , e3DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

5 Supplemental Fig 2 Decision tree for individuals with isolated café-au-lait macules (CALMs). Cutoff ages have been modified to simplify the use of the data. The numbers in the tables represent the total number of individuals in the clinical and in the molecular cohort along with the total combined numbers for each end point after age modification. NF1, Neurofibromatosis type 1. Journal of the American Academy of Dermatology  , e3DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

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