1. Gastro Intestinal drugs Groups Classiification Chemical name Brandname

2. Gastro Intestinal drugs-Groups
Antacids
Antispasmodics& drugs affecting gut motility.
Ulcer healing drugs
Antidiarrhoeal & antiemetic drugs
Laxatives
Ano-rectal preparations
Drugs affecting gastro intestinal secretion
Inflammatory bowel diseases.
Gastro esophageal disorders (GERD)

3. Ulcer healing drugs
Classification:- 1. Antacids(Neutralization of gastric acid)
eg. Sodium bicarbonate
Sod.citrate
Mg.hydroxide
Mg.trisilicate
Aluminium Hydroxide
Calcium carbonate
Magaldrate

4. Moxal Moxalplus Gaviscon Gestid Omacid Epicogel Medacid Actonorm gel
Maalox
Rennie

5. 2. Reduction of gastric acid secretion
(a). H2 receptor blockers:- Cimetidine
Ranitidine
Famotidine
Roxatidine

6. Brand names Ranitidine:- Zantac dose:- 75mg,150mg,300mg Histac Rantag
Antagonin
Ranid
Famotidine:- Famopsin mg, 20mg,40mg
Famodar
Pepcid

7. (b). Proton pump inhibitors:- Omeperazole
Lanzoprazole
Pantoprazole
Rabeperazole
Esomeperazole
( c) .Prostaglandin analogue:- Misoprostol
(d) Anticholinergics: Pirenzepine
Oxyphenonium
Propantheline

8. Brand names Omeperazole:- Omapro Pantoprazole:- Proton
Losec
Omiz
Omezyn
Omedar
Pantoprazole:- Proton
Pantodac
Lanzoprazole:- Lanzol
Takepron
Esomeprazole:- Nexium

9. 3.Ulcer protectives:- Sucralfate , CBS ( coloidal bismuth subcitrate)
4. Anti H.Pylori drugs :- Antibiotics

10. Drugs for Diarrhea and Constipation
Laxatives:- Drugs that promote evacuation of bowels
Classification : Bulk forming
eg.Dietary fibres:- Bran
Psyllium
Isphagula
Methyl cellulose
2. Stool softener: Docusates
Liquid paraffin

11. 3.Stimulant Purgatives:- Phenolphthalein
Bisacodyl
Sodium picosulfate
Senna
Cascara sagrada
Castor oil
4.Osmotic laxatives: Lactulose
Mg salts
Na. salts
Na.k. tartarate

12. Antidiarrhoeal drugs Rehydration therapy Oral rehydration therapy
Formula of ORS(WHO)
NaCl g
KCl 1.5g
Trisod. Citrate g
Glucose g
Water 1L
Brands:- ORS, Electral, Electrobion etc

13. Antidiarrhoeal drugs Anti motility drugs :- Codeine
Diphenoxylate: (Lomotil)
Loperamide
(Imodium)
Adsorbents : Kaolin
Antimicrobials: Metronidazole, Tinidazole
Ciprofloxacin, Nitrofurantoin etc

14. Antiemetics Anticholinergics:- Hyoscine, Dicyclomine
H1 antihistamines:- Promethazine
Diphenhydramine,
Dimenhydrinate
Doxylamine
Cyclizine, Meclizine
Cinnarizine

15. Antiemetics Prokinetic drugs:- Metoclopramide
Neuroleptics: Chlorpromazine
Prochlorperazine
Haloperidol
Prokinetic drugs:- Metoclopramide
Domperidone
Cisapride, Mosapride
Tegaserod

16. Antiemetics 5-HT3 Antagonists:- Ondansetron
Granisetron
Adjuvant Antiemetics:- Dexamethasone,
Benzodiazepines
Cannabinoids. etc

17. Brand names Hyoscine-N-Butyl bromide:- Buscopan
Scopinal
Hycom
Hyoscine Hydrobromide:- Scopalamine
Promethazine:- Avomine, Histazin,Histaloc.
Meclizine :- Navidoxime
Cinnarzine:- Stugeron

18. Brand names Prochlerapazine:- Stemetil
Metoclopramide:- Perinorm, Primepran
Premosan,Gastrenerton
Domperidone:- Motilium, Motilone, Dompy

19. GERD-( Gastro Esophageal Reflux Diseases)
PPIs
H2blockers
Antacids
Sodium Alginate
Prokinetic drugs

20. Inflammatory bowel diseases.
Inflammation of colon and small intestine
Two types :- 1. Ulcerative colitis
2. Crohn’s disease
Drugs used are (a) Aminosalicylates
(b) Corticosteroids.
(c) Drugs affects immune response

21. Inflammatory bowel diseases
Aminosalicylates:- drugs are,
Sulfasalazine
Mesalazine etc.
Corticosteroids:- Beclomethasone
Budesonide
Prednisolone
Hydrocprtisone
Drugs affects immune response:-
Azathioprine
Ciclosporine
Methotrexate
Mercaptopurine

22. H.Pylori Infection
Causative factor in all duodenal ulcers and gastric ulcers that are not associated with NSAID use.
Eradication involves a long term therapy.
Recommended Treatment regimen
Dual therapy :- 2 week
PPI + AB Triple therapy:- 2 week,1 week and 10 days followed by prophylatic single therapy,
PPI +AB+metronidazole