1. Dr. Maria Fedorova
DuPont Pioneer

2. Gene Editing for Crop Improvement
The plant does not have desired output
The plant does have desired output
DELETE
SEARCH / REPLACE
EDIT
The plant has tolerance to drought
The plant has high-tolerance to drought
The plant is susceptible to disease
The plant is resistant to disease
Precise, yet flexible, set of tools allowing to make
specific, targeted improvements to plant genomes
Uses genetic material from the same plant/crop -
no DNA from a different species in the end-product
Change similarly possible through conventional breeding
Targeted mutagenesis

3. Wide Array of Agricultural Applications
CRISPR-Cas Furthers Innovation for Pioneer® Brand Products
NEAR-TERM Pioneer® PRODUCT TO MARKET
NEXT GEN. WAXY CORN HYBRIDS
High amylopectin starch corn
Targeted mutation in the same gene as in the current waxy product
To market by end of current decade
Products, benefits and concepts described herein will not be offered for sale or distribution until completion of field testing and applicable regulatory reviews.

4. Vision for CRISPR-Cas at DuPont Pioneer

5. Gene Editing: Challenging Regulatory Paradigms
Regulatory policies are still in development in many countries
"Living modified organism" means any living organism that possesses a novel combination of genetic material obtained through the use of modern biotechnology”
Challenge: what is the appropriate policy framework to facilitate innovation while protecting human health and the environment?

6. Available processes or regulatory precedents
Regulatory Policies for Gene Editing
Available processes or
regulatory precedents
U.S. (USDA)
Canada
Argentina
Chile
Israel
Several EU MS
New Zealand (EPA)
policy in development

7. Considerations for Regulatory Policies
Appropriate, science-based regulatory oversight for plants developed with CRISPR-Cas advanced plant breeding, consistent with plants developed through other plant breeding methods
Gene edited plants are indistinguishable from plants that could be produced with conventional breeding tools and have a long history of safe use
It is the characteristics of the plant, not the production method, that determines its safety
Protecting health and the environment while promoting innovation
Science-based, accommodate new evidence and learning
Cost effective and commensurate with the risk
Transparent, consistently applied and enforced
Globally harmonized