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Healing of an Asymptomatic Carotid Plaque Ulceration
by Ye Qiao, Alik Farber, Elie Semaan, and James A. Hamilton Circulation Volume 118(10):e147-e148 September 2, 2008 Copyright © American Heart Association, Inc. All rights reserved.
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Figure 1. Plaque ulceration of the left internal carotid artery.
Figure 1. Plaque ulceration of the left internal carotid artery. A, In vivo T1W MRI at 3T (repetition time, 1 RR of cardiac cycle; echo time, 10 ms; echo train, 9; 1 average and with heart rate of 50 bpm). B, Gross inspection of the CEA specimen. C, Ex vivo T1W MRI at 11.7T of the specimen. D, Trichrome-stained matched histology. Arrows in A through D indicate plaque ulceration and hemorrhage. Ye Qiao et al. Circulation. 2008;118:e147-e148 Copyright © American Heart Association, Inc. All rights reserved.
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Figure 2. Healing of plaque ulceration and rupture: serial MRI of the right carotid artery with histology validation. Figure 2. Healing of plaque ulceration and rupture: serial MRI of the right carotid artery with histology validation. A, Magnetic resonance angiography showing internal (ICA), common (CCA), and external (ECA) carotid arteries and vertebral artery (VA); B, F, and J, Contiguous T1W MRI slices oriented at the lines in A. Plaque ulcerations are detected in the common carotid (arrows in J). C, G, and K, T1W MRI obtained 2 months later at the same location. Comparing to J, a new bright signal band is observed in K (arrows). D, H, and L, Matched histology with trichrome stain (Scale bar=1 mm). Blue-stained collagen-rich fibrous tissue is seen on top of red-stained hemorrhage of L, and it is thin in D and H. E, Fibrous cap disruption in the ICA (arrow, inset box of D). I, Immunostaining of glycophorin A (brown, inset box of H). M, Sirius red stain viewed under polarized light (inset box of L). Collagen type I is red and collagen type III is green. Ye Qiao et al. Circulation. 2008;118:e147-e148 Copyright © American Heart Association, Inc. All rights reserved.
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