1. Healing of an Asymptomatic Carotid Plaque Ulceration
by Ye Qiao, Alik Farber, Elie Semaan, and James A. Hamilton
Circulation
Volume 118(10):e147-e148
September 2, 2008
Copyright © American Heart Association, Inc. All rights reserved.

2. Figure 1. Plaque ulceration of the left internal carotid artery.
Figure 1. Plaque ulceration of the left internal carotid artery. A, In vivo T1W MRI at 3T (repetition time, 1 RR of cardiac cycle; echo time, 10 ms; echo train, 9; 1 average and with heart rate of 50 bpm). B, Gross inspection of the CEA specimen. C, Ex vivo T1W MRI at 11.7T of the specimen. D, Trichrome-stained matched histology. Arrows in A through D indicate plaque ulceration and hemorrhage.
Ye Qiao et al. Circulation. 2008;118:e147-e148
Copyright © American Heart Association, Inc. All rights reserved.

3. Figure 2. Healing of plaque ulceration and rupture: serial MRI of the right carotid artery with histology validation.
Figure 2. Healing of plaque ulceration and rupture: serial MRI of the right carotid artery with histology validation. A, Magnetic resonance angiography showing internal (ICA), common (CCA), and external (ECA) carotid arteries and vertebral artery (VA); B, F, and J, Contiguous T1W MRI slices oriented at the lines in A. Plaque ulcerations are detected in the common carotid (arrows in J). C, G, and K, T1W MRI obtained 2 months later at the same location. Comparing to J, a new bright signal band is observed in K (arrows). D, H, and L, Matched histology with trichrome stain (Scale bar=1 mm). Blue-stained collagen-rich fibrous tissue is seen on top of red-stained hemorrhage of L, and it is thin in D and H. E, Fibrous cap disruption in the ICA (arrow, inset box of D). I, Immunostaining of glycophorin A (brown, inset box of H). M, Sirius red stain viewed under polarized light (inset box of L). Collagen type I is red and collagen type III is green.
Ye Qiao et al. Circulation. 2008;118:e147-e148
Copyright © American Heart Association, Inc. All rights reserved.