1. Primitive Macrophages Drive Coronary Development
by Clinton S. Robbins, and Rickvinder Besla
Circulation Research
Volume 118(10):
May 13, 2016
Copyright © American Heart Association, Inc. All rights reserved.

2. Localization of functionally distinct embryonic macrophage subsets in the developing heart.
Localization of functionally distinct embryonic macrophage subsets in the developing heart. Primitive yolk sac–derived CCR2− macrophages are located in the myocardial wall and promote the selective expansion of perfused coronary vasculature during development. In contrast, CCR2+ macrophages arise from lymphomyeloid progenitors and, to a greater extent, fetal liver monocytes. CCR2+ embryonic macrophages associate with the endocardial trabeculae and are dispensable for coronary development.
Clinton S. Robbins, and Rickvinder Besla Circ Res. 2016;118:
Copyright © American Heart Association, Inc. All rights reserved.