Presentation is loading. Please wait.

Presentation is loading. Please wait.

DNA identification pathway

Published byよしお あんさい Modified over 6 years ago

Similar presentations

Presentation on theme: "DNA identification pathway"— Presentation transcript:

1 DNA identification pathway
Lab Infer Evidence item Evidence data Evidence genotype 10, 12 Compare Known genotype 10, 12

2 Human interpretation issues
• call good data inconclusive • peaks are too low for them • too many contributors to handle • potential examination bias

3 DNA pathway broken Lab Infer Evidence item Evidence data
Evidence genotype ??? + Compare Known genotype 10, 12

4 TrueAllele® Casework • preserve data information
• use all peaks, high or low • any number of contributors • entirely objective, no bias • crime lab data, TrueAllele science

5 DNA pathway restored Lab Infer Evidence item Evidence data
Evidence genotype 10, 30% 10, 50% 10, 20% + Compare Known genotype 10, 12

6 National DNA Mixture Crisis
375 cases/year x 4 years = 1,500 cases 320 M in US / 8 M in VA = 40 factor 1,500 cases x 40 factor = 60,000 inconclusive 1,000 cases/year x 4 years = 4,000 cases 320 M in US / 8 M in NY = 40 factor 4,000 cases x 40 factor = 160,000 inconclusive + underreporting of DNA match statistics DNA evidence data in 100,000 cases Collected, analyzed & paid for – but unused

7 DNA database pathway Evidence Reference Genotype database
Match & Report Infer & Upload Crime scene Criminals

8 Old-style database issues
• upload only 10% of mixtures • hit by association, not by match • comparison: make false hits • restrict upload: lose true hits

9 20th century DNA database
Evidence Reference Allele database Allele database Match & Report Infer & Upload Crime scene Criminals +

10 TrueAllele® Database • upload all mixture evidence
• hit based on LR match statistic • sensitive: find true hits • specific: only true hits • crime lab data, TrueAllele science

11 21st century DNA database
Evidence Reference Genotype database Genotype database Match & Report Infer & Upload Crime scene Criminals +

Download ppt "DNA identification pathway"

Similar presentations

Overcoming DNA Stochastic Effects 2010 NEAFS & NEDIAI Meeting November, 2010 Manchester, VT Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics.

Overcoming DNA Stochastic Effects 2010 NEAFS & NEDIAI Meeting November, 2010 Manchester, VT Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics.
DNA Mixture Interpretations and Statistics – To Include or Exclude Cybergenetics © 2003-2013 Prescription for Criminal Justice Forensics ABA Criminal Justice.

DNA Mixture Interpretations and Statistics – To Include or Exclude Cybergenetics © Prescription for Criminal Justice Forensics ABA Criminal Justice.
The Way Forward in the UK

The Way Forward in the UK
Finding Truth in DNA Mixture Evidence Innocence Network Conference April, 2013 Charlotte, NC Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA.

Finding Truth in DNA Mixture Evidence Innocence Network Conference April, 2013 Charlotte, NC Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA.
How Inclusion Interpretation of DNA Mixture Evidence Reduces Identification Information American Academy of Forensic Sciences February, 2013 Washington,

How Inclusion Interpretation of DNA Mixture Evidence Reduces Identification Information American Academy of Forensic Sciences February, 2013 Washington,
Creating informative DNA libraries using computer reinterpretation of existing data Northeastern Association of Forensic Scientists November, 2011 Newport,

Creating informative DNA libraries using computer reinterpretation of existing data Northeastern Association of Forensic Scientists November, 2011 Newport,
Preventing rape in the military through effective DNA computing Forensics Europe Expo Forensics Seminar Theatre April, 2014 London, UK Mark W Perlin, PhD,

Preventing rape in the military through effective DNA computing Forensics Europe Expo Forensics Seminar Theatre April, 2014 London, UK Mark W Perlin, PhD,
Coding a Safer Society through Computer Interpretation of DNA Evidence Cybergenetics © 2003-2014 MATLAB Virtual Conference March, 2014 Mark W Perlin, PhD,

Coding a Safer Society through Computer Interpretation of DNA Evidence Cybergenetics © MATLAB Virtual Conference March, 2014 Mark W Perlin, PhD,
TrueAllele ® Interpretation of DNA Mixture Evidence 9 th International Conference on Forensic Inference and Statistics August, 2014 Leiden University,

TrueAllele ® Interpretation of DNA Mixture Evidence 9 th International Conference on Forensic Inference and Statistics August, 2014 Leiden University,
TrueAllele ® Casework Validation on PowerPlex ® 21 Mixture Data Australian and New Zealand Forensic Science Society September, 2014 Adelaide, South Australia.

TrueAllele ® Casework Validation on PowerPlex ® 21 Mixture Data Australian and New Zealand Forensic Science Society September, 2014 Adelaide, South Australia.
Kern Regional Crime Laboratory Laboratory Director: Dr. Kevin W. P. Miller TRUEALLELE® WORK AND WORKFLOW: KERN COUNTY’S FIRST CASES APRIL 23, 2014.

Kern Regional Crime Laboratory Laboratory Director: Dr. Kevin W. P. Miller TRUEALLELE® WORK AND WORKFLOW: KERN COUNTY’S FIRST CASES APRIL 23, 2014.
Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.

Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.
Expert Systems for Automated STR Analysis SWGDAM Quantico, VA Mark W. Perlin January, 2003.

Expert Systems for Automated STR Analysis SWGDAM Quantico, VA Mark W. Perlin January, 2003.
No DNA Left Behind: When inconclusive really means informative Schenectady County District Attorney’s Office January, 2014 Mark W Perlin, PhD, MD,

No DNA Left Behind: When "inconclusive" really means "informative" Schenectady County District Attorney’s Office January, 2014 Mark W Perlin, PhD, MD,
Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.

Revolutionising DNA analysis in major crime investigations The Investigator Conferences Green Park Conference Centre May, 2014 Aylesbury, Buckinghamshire.
Solving Cold Cases by TrueAllele ® Analysis of DNA Evidence Finding Closure: The Science, Law and Politics of Cold Case Investigations October, 2014 Pittsburgh,

Solving Cold Cases by TrueAllele ® Analysis of DNA Evidence Finding Closure: The Science, Law and Politics of Cold Case Investigations October, 2014 Pittsburgh,
Scientific Validation of Mixture Interpretation Methods 17th International Symposium on Human Identification Sponsored by the Promega Corporation October,

Scientific Validation of Mixture Interpretation Methods 17th International Symposium on Human Identification Sponsored by the Promega Corporation October,
Computer Interpretation of Uncertain DNA Evidence National Institute of Justice Computer v. Human June, 2011 Arlington, VA Mark W Perlin, PhD, MD, PhD.

Computer Interpretation of Uncertain DNA Evidence National Institute of Justice Computer v. Human June, 2011 Arlington, VA Mark W Perlin, PhD, MD, PhD.
Using Expert Systems (TrueAllele ® ) for Forensic STR DNA Analysis National Institute of Justice Grantees Meeting 2011 Using Expert Systems (TrueAllele.

Using Expert Systems (TrueAllele ® ) for Forensic STR DNA Analysis National Institute of Justice Grantees Meeting 2011 Using Expert Systems (TrueAllele.
TrueAllele ® Genetic Calculator: Implementation in the NYSP Crime Laboratory NYS DNA Subcommittee May 19, 2010 Barry Duceman, Ph.D New York State Police.

TrueAllele ® Genetic Calculator: Implementation in the NYSP Crime Laboratory NYS DNA Subcommittee May 19, 2010 Barry Duceman, Ph.D New York State Police.

Similar presentations

Ads by Google