1. By Tyler Gagan BME 281 Section 2
Tissue Engineering
By Tyler Gagan
BME 281 Section 2

2. Overview Isolation of patients cell Creation of synthetic scaffold
Proliferation of cells onto scaffold

3. History
1970’s: (John F. Burke) First skin substitute. Purified shark collagen, long sugar molecule.
1970’s-1980’s First successful human derived skin substitute procedure (Howard Green, Harvard Medical)

4. Modern Application Repair of damaged cells
Replacing non-existent cells
Artificial organ parts/entire organs

5. Limitations Very long cell adhesion time.
Thick tissues need vascularization.
Proper cell environment is tough to mimic.
micrometers thick (diffusion limit for Oxygen)

6. Future Increased growth rate and adhesion rate
Growth of entirely biocompatible organs.
Stocked tissue databases.

7. Sources
"Research Current Research Programs." Pittsburgh Tissue Engineering Initiative. N.p., n.d. Web. 08 Oct <
"Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges." - Annual Review of Chemical and Biomolecular Engineering, 2(1):403. N.p., n.d. Web. 08 Oct <
"Tissue Engineering." Tissue Engineering. N.p., n.d. Web. 08 Oct <
"Tissue-Engineering." Tissue-Engineering. N.p., n.d. Web. 08 Oct <