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By Tyler Gagan BME 281 Section 2
Tissue Engineering By Tyler Gagan BME 281 Section 2
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Overview Isolation of patients cell Creation of synthetic scaffold
Proliferation of cells onto scaffold
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History 1970’s: (John F. Burke) First skin substitute. Purified shark collagen, long sugar molecule. 1970’s-1980’s First successful human derived skin substitute procedure (Howard Green, Harvard Medical)
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Modern Application Repair of damaged cells
Replacing non-existent cells Artificial organ parts/entire organs
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Limitations Very long cell adhesion time.
Thick tissues need vascularization. Proper cell environment is tough to mimic. micrometers thick (diffusion limit for Oxygen)
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Future Increased growth rate and adhesion rate
Growth of entirely biocompatible organs. Stocked tissue databases.
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Sources "Research Current Research Programs." Pittsburgh Tissue Engineering Initiative. N.p., n.d. Web. 08 Oct < "Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges." - Annual Review of Chemical and Biomolecular Engineering, 2(1):403. N.p., n.d. Web. 08 Oct < "Tissue Engineering." Tissue Engineering. N.p., n.d. Web. 08 Oct < "Tissue-Engineering." Tissue-Engineering. N.p., n.d. Web. 08 Oct <
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