1. Oesophageal Cancer
Aaron Hui

2. Introduction 2 Main types (squamous and adenocarcinoma)
Incidence of adenocarcinoma is rising
3-4 / Western society
Poor Prognosis

3. Pathophysiology Chronic Mucosal irritation Genetic factors
Environmental factors

4. Squamous Cell Adenocarcinoma Demographic and socioeconomic factors
Gastroesophageal reflux disease
Smoking and alcohol
Smoking
Dietary factors
Alcohol
Underlying oesophageal disease 
Obesity
Human papilloma virus
Helicobacter pylori infection 
Bisphosphonates 
Increased oesophageal acid exposure 
Use of drugs that decrease lower oesophageal sphincter pressure

8. Barrett’s Eosophagus

9. Clinical presentation
-Dysphagia
-Weight loss
-Routine screening for Barrett’s
-Hoarseness
Distant metastasis
Paraneoplastic syndrome

10. Diagnosis
Barium Studies
Gastroscopy
CT, PET
EUS

13. Surgical Treatment

14. Gastric Cancer
Aaron Hui

15. Introduction Majority adenocarcinoma
50% of people have locally advanced disease at time of presentation
2 main types
A proven infectious agent

17. Pathophysiology Intestinal-type (well-differentiated)
Pre neoplastic cascade:
1. Non atrophic gastritis  2. Atrophic gastritis  3. Intestinal Metaplasia  4. Dysplasia  5. Invasive Carcinoma
Diffuse type (poorly differentiated)
- E-cadherin

19. Diagnosis
Barium studies
Gastroscopy
High resolution Helical Abdo CT

23. Surgical Treatment