1. by Jeffrey R. Martens, and Craig H. Gelband
Alterations in Rat Interlobar Artery Membrane Potential and K+ Channels in Genetic and Nongenetic Hypertension
by Jeffrey R. Martens, and Craig H. Gelband
Circulation Research
Volume 79(2):
August 1, 1996
Copyright © American Heart Association, Inc. All rights reserved.

2. Isolation of K(v) and K(Ca) current in WKY and SHR interlobar artery cells.
Isolation of K(v) and K(Ca) current in WKY and SHR interlobar artery cells. A, In the presence of 4-AP (10 mmol/L) and niflumic acid (100 μmol/L), SHR K(Ca) current was significantly greater than WKY K(Ca) current. Similar results were obtained in seven cells. Voltage-ramp and -step depolarizations are shown at the top and bottom of the panel, respectively. B, In the presence of charybdotoxin (100 nmol/L) and niflumic acid (100 μmol/L), WKY K(v) current was significantly greater than SHR K(v) current. Similar results were obtained in seven cells. Voltage-ramp and -step depolarizations are shown at the top and bottom of the panel, respectively. These two cells had similar membrane capacitances (WKY, 26 pF; SHR, 27 pF).
Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:
Copyright © American Heart Association, Inc. All rights reserved.

3. Isolation of K(v) current in SD and DOCA hypertensive interlobar artery cells.
Isolation of K(v) current in SD and DOCA hypertensive interlobar artery cells. In the presence of charybdotoxin (100 nmol/L) and niflumic acid (100 μmol/L), SD K(v) current was significantly greater than DOCA hypertensive K(v) current during step depolarizations (holding potential, −80 mV; test potential, −20 mV to 80 mV; 20-mV steps) and ramp depolarizations (−80 to 80 mV, 4 seconds). The membrane capacitances of the two cells were similar (SD, 30 pF; DOCA, 29 pF). Similar results were obtained in seven cells.
Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:
Copyright © American Heart Association, Inc. All rights reserved.

4. Isolation of K(Ca) current in SD and DOCA hypertensive interlobar artery cells.
Isolation of K(Ca) current in SD and DOCA hypertensive interlobar artery cells. In the presence of 4-AP (10 mmol/L) and niflumic acid (100 μmol/L), DOCA hypertensive K(Ca) current was significantly greater than SD K(Ca) current during step depolarizations (A; holding potential, −80 mV; test potential, −20 to 70 mV; 10-mV steps) and ramp depolarizations (B, −80 to 80 mV, 4 seconds). These two cells had similar membrane capacitances (SD, 29 pF; DOCA, 30 pF). Similar results were obtained in seven cells.
Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:
Copyright © American Heart Association, Inc. All rights reserved.

5. Mean current-voltage relationships for K(v) and K(Ca) currents in SD and DOCA hypertensive cells.
Mean current-voltage relationships for K(v) and K(Ca) currents in SD and DOCA hypertensive cells. DOCA hypertensive K(v) current (A) and K(Ca) current (B) are significantly altered compared with control (n=7). Error bars are the same size as the symbol and therefore are not visible.
Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:
Copyright © American Heart Association, Inc. All rights reserved.

6. Basal and Ang II–stimulated [Ca2+]i.
Basal and Ang II–stimulated [Ca2+]i. Both basal and Ang II–stimulated [Ca2+]i are significantly different from control (n=7, P<.05).
Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:
Copyright © American Heart Association, Inc. All rights reserved.