Presentation is loading. Please wait.

Presentation is loading. Please wait.

Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation  Khalid M. El-Say, Tarek.

Published byAna María Castro Rodríguez Modified over 6 years ago

Similar presentations

Presentation on theme: "Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation  Khalid M. El-Say, Tarek."— Presentation transcript:

1 Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation  Khalid M. El-Say, Tarek A. Ahmed, Osama A.A. Ahmed, Khaled M. Hosny, Fathy I. Abd-Allah  Journal of Pharmaceutical Sciences  Volume 106, Issue 9, Pages (September 2017) DOI: /j.xphs Copyright © 2017 American Pharmacists Association® Terms and Conditions

2 Figure 1 Estimated response surface (3D) (a) and triangular dimensional contour plots (b) showing the effect of the mixture components on the globule size. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

3 Figure 2 Release profiles of vitamin K from different SNELT formulations (F1-F6) and the commercial tablet. Each value represents the mean ± SD (n = 3). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

4 Figure 3 Fourier transform infrared spectra of pure vitamin K and tablet ingredients as well as components of SNEDDS. Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

5 Figure 4 Photomicrographs of the SNELT surfaces by optical microscope images at 400× magnification power (a-f represent F1-F6, respectively). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

6 Figure 5 Scanning electron microscopy photomicrographs of the SNELT formulations (a-f represent F1-F6, respectively). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

7 Figure 6 Plasma concentration-time profiles of vitamin K after intramuscular and oral administration of commercial vitamin K products and oral administration of vitamin K SNELTs to human volunteers. Each value represents the mean ± SD (n = 6). *p < 0.05 compared to the commercial vitamin K tablet (oral); #p < 0.05 compared to the commercial vitamin K ampoule (IM). Journal of Pharmaceutical Sciences  , DOI: ( /j.xphs ) Copyright © 2017 American Pharmacists Association® Terms and Conditions

Download ppt "Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation  Khalid M. El-Say, Tarek."

Similar presentations

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
An Evaluation of the Accuracy and Precision of a Stand-Alone Submersible Continuous Ruminal pH Measurement System1 G.B. Penner, K.A. Beauchemin, T. Mutsvangwa.

An Evaluation of the Accuracy and Precision of a Stand-Alone Submersible Continuous Ruminal pH Measurement System1 G.B. Penner, K.A. Beauchemin, T. Mutsvangwa.
Angiotensin-I-converting enzyme-inhibitory peptides in commercial Wisconsin Cheddar cheeses of different ages Y. Lu, S. Govindasamy-Lucey, J.A. Lucey Journal.

Angiotensin-I-converting enzyme-inhibitory peptides in commercial Wisconsin Cheddar cheeses of different ages Y. Lu, S. Govindasamy-Lucey, J.A. Lucey Journal.
Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages 20-31 (January 2004) DOI: 10.3168/jds.S0022-0302(04)73137-9.

Effects of Milk Powders in Milk Chocolate B. Liang, R.W. Hartel Journal of Dairy Science Volume 87, Issue 1, Pages (January 2004) DOI: /jds.S (04)
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages 332-384 (March.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake Tom De Bruyn, Bruno Stieger, Patrick F. Augustijns, Pieter P. Annaert Journal.

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake Tom De Bruyn, Bruno Stieger, Patrick F. Augustijns, Pieter P. Annaert Journal.
Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,

Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,
Quantitative measurement of vitamin K2 (menaquinones) in various fermented dairy products using a reliable high-performance liquid chromatography method.

Quantitative measurement of vitamin K2 (menaquinones) in various fermented dairy products using a reliable high-performance liquid chromatography method.
Celiac Disease Genetics: Current Concepts and Practical Applications Ludvig M. Sollid, Benedicte A. Lie Clinical Gastroenterology and Hepatology Volume.

Celiac Disease Genetics: Current Concepts and Practical Applications Ludvig M. Sollid, Benedicte A. Lie Clinical Gastroenterology and Hepatology Volume.
Patient request for pharmacist counseling and satisfaction: Automated prescription delivery system versus regular pick-up counter Jan D. Hirsch, PhD Journal.

Patient request for pharmacist counseling and satisfaction: Automated prescription delivery system versus regular pick-up counter Jan D. Hirsch, PhD Journal.
Inbreeding in Danish Dairy Cattle Breeds A.C. Sørensen, M.K. Sørensen, P. Berg Journal of Dairy Science Volume 88, Issue 5, Pages 1865-1872 (May 2005)

Inbreeding in Danish Dairy Cattle Breeds A.C. Sørensen, M.K. Sørensen, P. Berg Journal of Dairy Science Volume 88, Issue 5, Pages (May 2005)
Comparison of functional properties of 34% and 80% whey protein and milk serum protein concentrates P.J. Luck, B. Vardhanabhuti, Y.H. Yong, T. Laundon,

Comparison of functional properties of 34% and 80% whey protein and milk serum protein concentrates P.J. Luck, B. Vardhanabhuti, Y.H. Yong, T. Laundon,
Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice M. Murata, T. Satoh, H. Wakabayashi, K. Yamauchi,

Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice M. Murata, T. Satoh, H. Wakabayashi, K. Yamauchi,
Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism ‐ Based Prediction of Volume of Distribution Patrick Poulin, Frank ‐ Peter Theil.
Assessment of the Immunogenicity of Mechanically Induced Interferon Aggregates in a Transgenic Mouse Model Paul Human, Helen Ilsley, Cynthia Roberson,

Assessment of the Immunogenicity of Mechanically Induced Interferon Aggregates in a Transgenic Mouse Model Paul Human, Helen Ilsley, Cynthia Roberson,
Volume 104, Issue 6, Pages (December 1993)

Volume 104, Issue 6, Pages (December 1993)
Hsiaoling Wang, Nagarani Pampati, William M

Hsiaoling Wang, Nagarani Pampati, William M
Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao.

Paclitaxel-Loaded Magnetic Nanoparticles: Synthesis, Characterization, and Application in Targeting  Jilai Tian, Caiyun Yan, Kunliang Liu, Juan Tao, Zhenchao.
Iurii Antoniuk, Catherine Amiel  Journal of Pharmaceutical Sciences 

Iurii Antoniuk, Catherine Amiel  Journal of Pharmaceutical Sciences 
Pediatric Drugs-A Review of Commercially Available Oral Formulations

Pediatric Drugs-A Review of Commercially Available Oral Formulations

Similar presentations

Ads by Google