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Enteric pathogen bacteria
Enterobacteriaceae Gram negative Exotoxin enterotoxin Endotoxin in cell walls(LPS)
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Antigens 3 major groups of antigens: Somatic O Lipopolysacharides
Capsular K antigens / Vi antigen Flagellar H proteins
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Virulence Factors Enterotoxin Capsule Antigenic phase variation
Exotoxin production Adhesion factors Intracellular survival and multiplication protecting from antibiotic&immune reaction
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Antimicrobial resistance exposure to antibiotic
Resistance to serum killing capsule
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Endotoxin. Lipid A component of LPS Release upon cell death & lysis Endotoxin Mediated Toxicity: Fever Leukopenia Activation of complement Thrombocytopenia
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- Disseminated Intravascular coagulation
- Decreased peripheral circulation - Shock - Death Exotoxin production Enterotoxin Shiga&shiga like toxin cytotoxic,enterotoxic Hemolysins
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Desease due to Enterobacteriaceae
Intestinal Infections Pathogenic processesinvasive 2. Extra intestinal Infections Enteric commensals opportunistic pathogens
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Enteritis : non bloody diarrhea
Septicemia Enteric fever Asymptomatic carriage/chronic carriage Shigellosis: pus&bloody in the stoolmucosal ulceration.
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Pathogenesis Bacteremia- Septicemia
Ingestion of bacteriasmall intestine mesenteric lymph node bacteremia RES system(multiplication)septicemia and BileGall bladder:. Cholecystitis . Carriage stage Inflamation&ulceration of Peyer’s patches
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2. Infection is limited to the mucosa and sub mucosa of the intestine
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Clinically Significant Nonfermentative Gram Negative Bacilli
Pseudomonas Acinetobacter Virulence Factors Assosiated with Pseudomonas: . Pili . Exotoxin . Capsule . Enzymes . Endotoxin
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Infections Opportunistic pathogen Bacteremia Endocarditis
Pulmonary Infections Ear Infection Burn wound Infection UTI Eye Infections ,ect
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