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Enteric pathogen bacteria

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Presentation on theme: "Enteric pathogen bacteria"— Presentation transcript:

1 Enteric pathogen bacteria
Enterobacteriaceae Gram negative Exotoxin  enterotoxin Endotoxin in cell walls(LPS)

2 Antigens 3 major groups of antigens: Somatic O Lipopolysacharides
Capsular K antigens / Vi antigen Flagellar H proteins

3 Virulence Factors Enterotoxin Capsule Antigenic phase variation
Exotoxin production Adhesion factors Intracellular survival and multiplication  protecting from antibiotic&immune reaction

4 Antimicrobial resistance  exposure to antibiotic
Resistance to serum killing  capsule

5 Endotoxin. Lipid A component of LPS Release upon cell death & lysis Endotoxin Mediated Toxicity: Fever Leukopenia Activation of complement Thrombocytopenia

6 - Disseminated Intravascular coagulation
- Decreased peripheral circulation - Shock - Death Exotoxin production Enterotoxin Shiga&shiga like toxin cytotoxic,enterotoxic Hemolysins

7 Desease due to Enterobacteriaceae
Intestinal Infections Pathogenic processesinvasive 2. Extra intestinal Infections Enteric commensals opportunistic pathogens

8 Enteritis : non bloody diarrhea
Septicemia Enteric fever Asymptomatic carriage/chronic carriage Shigellosis: pus&bloody in the stoolmucosal ulceration.

9 Pathogenesis Bacteremia- Septicemia
Ingestion of bacteriasmall intestine mesenteric lymph node  bacteremia RES system(multiplication)septicemia and BileGall bladder:. Cholecystitis . Carriage stage  Inflamation&ulceration of Peyer’s patches

10 2. Infection is limited to the mucosa and sub mucosa of the intestine

11 Clinically Significant Nonfermentative Gram Negative Bacilli
Pseudomonas Acinetobacter Virulence Factors Assosiated with Pseudomonas: . Pili . Exotoxin . Capsule . Enzymes . Endotoxin

12 Infections Opportunistic pathogen Bacteremia Endocarditis
Pulmonary Infections Ear Infection Burn wound Infection UTI Eye Infections ,ect


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