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Disseminated Intravascular Coagulation
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DIC Clinicopathologic syndrome characterized by widespread intravascular fibrin formation in response to excessive blood protease activity that overcomes the natural anticoagulant mechanism Leads to the consumption of procoagulants and platelets
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Common Clinical Causes of DIC
Sepsis Trauma and tissue injury Vascular disorders *Obstetric complications Cancer *Bacterial (staph, strep, pneumococci, gram (-) bacilli Viral Mycotic Parasitic Rickettsial Brain injury (gun shot) Extensive burns Fat embolism rhabdomyolysis Giant hemangiomas (Kasabach-Merrit syndrome) Large vessel aneurysm (aorta) Abruptio placentae Amniotic fluid embolism Dead fetus syndrome Septic abortion Adenocarcino-ma ( prostate, pancreas) Hematologic malignancies *(Acute promyelocytic anemia) * Most common causes of DIC
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Common Clinical Causes of DIC
Immunologic disorders Drugs Envenomation Liver disease miscellaneous Acute hemolytic transfusion reaction Organ or tissue transplant rejection Graft-versus-host disease Fibrinolytic agents Aprotinin Warfarin (esp. in neonates w/ protein C deficiency) Prothrombin complex concentrates Recreational drugs (amphetamine) Snakes Insects Fulminant hepatic failure Cirrhosis Fatty liver of pregnancy Shock Respiratory distress syndrome Massive transfusion
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