1. Lurie Children’s Strategic Research Initiative: Perinatal Origins of Childhood Disease: Research and Prevention at the Maternal-Fetal Interface
A DevSci Healthier Earlier Translational Partnership
MOVING THE HEALTHIER, EARLIER DIAL
PROMOTING HEALTHY BRAIN DEVELOPMENT
First experimental effort to improve adverse neurodevelopmental outcomes by reducing prenatal stress
Approach designed for rapid clinical and community-based application
Critical evidence base necessary for driving comprehensive pediatric health promotion beginning prenatally
Blending advances in prevention science, health technology, developmental science, and neuroscience transforms capacity to alter health trajectories before birth
Design
Randomized controlled trial (n = 200) pregnant women
Prenatal Intervention
Customized prenatal stress reduction
Mindfulness enhancement
Tailored feedback
Neurodevelopmental Outcomes
(birth – 1 year)
Natural sleep MRI
Eye tracking
Developmental phenotyping
BLENDING DIVERSE PERSPECTIVES AROUND A COMMON DEVELOPMENTAL QUESTION
Elizabeth Norton, PhD
Developmental Cognitive Neuroscientist, CSD/SOC
How does early life stress alter the trajectory of the developing brain?
Amelie Petitclerc, PhD
Developmental/Clinical Psychologist, MSS/FSM
What is the earliest developmental timepoint that child disruptive behavior can be prevented?
Laurie Wakschlag, PhD (PI)
Developmental Psychologist, MSS/FSM
Does early life stress cause adverse neurodevelopmental outcomes?
Darius Tandon, PhD
Community Psychologist,
MSS/FSM & CCH/NUCATS
What is the impact of a tailored, mindfulness-enhanced prenatal stress reduction intervention on maternal wellbeing?
Judy Moskowitz, PhD, MPH
Social Psychologist, MSS/FSM & Osher Center for Integrative Medicine
Can subjective stress / emotion ratings determine optimal delivery timing of tailored stress-reduction feedback?
UNIFYING OBJECTIVE: DISCOVER WHETHER IMPROVING GESTATIONAL BIOLOGY IMPROVES EARLY NEURODEVELOPMENTAL HEALTH
William Grobman, MD, MBA
Maternal:Fetal Medicine,
OB-Gyn/FSM
Are obstetric outcomes following a tailored prenatal stress reduction intervention affected by race, ethnicity, and socioeconomic status?
Brad Marino, MD, MPP, MSCE, FAHA
Pediatrician, PEDS/FSM/Lurie Children’s
Can prenatal prevention improve quality of life for high risk infants?
Michael Bass, MS
Health Information Technologist, MSS/FSM
What are the human computer interaction factors related to developing viable technology-assisted prenatal interventions?
John Rogers, PhD
Bioengineer &
Materials Scientist,
McCormick
Can unobtrusive smart physiological stress monitoring devices detect stress levels in pregnant women?
Nabil Alshurafa, PhD
Computer Scientist,
Prev Med/FSM & EECS/McCormick
What is the optimal predictive algorithm to detect real-time maternal stress response?