1. 11/29-Don’t Forget About Snork!!
Last day to re-take Protein Synthesis Quiz!
Begin working on the Protein Synthesis Diagram Warm-up.
Have Dan’s Plan and your stamp sheet out on your table!

2. Let’s Review Mutation https://www.youtube.com/watch?v=GieZ3pk9YVo

3. Chromosomes A Chromosome is a bundle of DNA wrapped by proteins
found in nucleus of Eukaryotes.

4. Chromosomal mutation
Chromosomal mutation - changes in a part of, or the entire, chromosome.
Result in: change in location of genes or number of genes

5. Types of Chromosomal Mutation
Deletion
Duplication
Inversion
Translocation

6. Deletion
Loss of all or part of a chromosome.

7. Duplication
Produces extra parts of a chromosome.

8. Inversion
Reverses the direction of parts of chromosomes.

9. Translocation
When part of one chromosome breaks off and attaches to another.

10. Mutation Card sort
Deletion- 4 cards Translocation- 4 cards Substitution- 3 cards Insertion- 1 card Duplication- 1 card Inversion- 1 card

11. Copy the words above into your notebook.
Stop Rat Live
Copy the words above into your notebook.

12. Reverse each words
Example: Rat  Tar
Does the meaning change?

13. StopPots RatTar LiveEvil

14. Menus
Have you ever ordered something from a fast food restaurant and the order turned out to be incorrect?
What lead to that error?

15. What happens to changes in instructions?
What makes the orders for protein synthesis in our body?
What do you think would happen if that order got changed?
Watch video:
I will create changes in words and sentences and explain how these changes represent mutations in DNA.

16. Objective:
We will identify and illustrate changes in DNA and evaluate the significance of those changes.
I will create changes in words and sentences and explain how these changes represent mutations in DNA.
I will create changes in words and sentences and explain how these changes represent mutations in DNA.

17. Does our body make errors?
Yes it does! Its called Mutations!

18. What is a mutation? (write this in your half sheet)
A mutation is:
Any change in the sequence of DNA (1 or more nucleotides)
Can be caused by radiation or chemicals
A natural event

19. What is a mutation? (write this in your half sheet)
A mutation is:
Not always harmful
Does not always affect phenotype (physical appearance)
Produces genetic variation in organisms (Different genes/DNA)

20. What is a mutation? A mutation is:
Any change in the sequence of DNA (1 or more nucleotides)
Mutation may be harmful or beneficial or no effect

21. Gene (DNA) Mutations Substitution Deletion Insertion
Substitution
Deletion
Insertion

22. Point Mutation (write this in your notebook)
Point mutation - Mutations that involves changes in one or a few nucleotides.
Only affect One amino acid

23. Substitution (write this in your foldable)
Where one DNA nucleotide is replaced (substituted) for another.

24. Question How might a substitution mutation affect protein synthesis?
Factory Defect?
I will create changes in words and sentences and explain how these changes represent mutations in DNA.

25. Point Mutation – Substitution Example: Sickle Cell anemia

26. Sickle Cell anemia http://www.youtube.com/watch?v=2CsgXHdWqVs

27. Frame-shift Mutation (write this in your notebook)
Frame-shift Mutation – mutation that shifts the “reading” frame of the genetic code by inserting or deleting a nucleotide.
More than one or more nucleotide will be changed.
Example:
Insertion
Deletion

28. Thesunwashotbuttheoldmandidnotgethishat.
If you were to split this sentence into individual three-letter words, you would probably read it like this:
The sun was hot but the old man did not get his hat.

29. Frame Shift (By: learn genetics)
This sentence represents a gene. Each letter corresponds to a nucleotide base, and each word represents a codon.
What if you shifted the three-letter "reading frame?" You would end up with
T hes unw ash otb utt heo ldm and idn otg eth ish at. Or
Th esu nwa sho tbu tth eol dma ndi dno tge thi sha t.

30. Deletion Mutation (write this in your foldable)
One or more nucleotides is removed from the DNA sequence.
Every amino acid after the deletion will be changed.

31. Insertion Mutation (write this in your foldable)
An addition of nucleotide is added (inserted) to the DNA sequence
Every amino acid after the insertion will be changed. C

32. Question How would an insertion or deletion affect protein synthesis?
What has the greatest affect on the resulting protein? Substitution or Insertion/Deletion?
I will create changes in words and sentences and explain how these changes represent mutations in DNA.

33. What could happen when the codes on the DNA changes?

34. Word Game!
I will create changes in words and sentences and explain how these changes represent mutations in DNA.

35. Copy these words into your notebook.
Milk Wisp Four Food
Copy these words into your notebook.

36. Change a letter each word
Write down each change you made.
Come up with as many new words as you can for each word.
Example:
Milk Mile

37. Milk Mile WispWise FourFoul FoodFool

38. The entrance to the park was closed.
Copy the above sentence into your notebook.

39. Erase the letter “d” from the word “closed”
Reread the sentence.
What does it say now?
Is the meaning still the same?
The entrance to the park was close.

40. Sentence mutation The entrance to the park was closed.

41. Copy the words above into the your notebook.
Ton At Red
Copy the words above into the your notebook.

42. Add a new letter to each words
Make sure the new word has a meaning.
Example: once  ounce
Does the word still have the same meaning with the addition of a new letter?

43. TonTone AtAte RedRead

44. Practice mutation worksheet

45. Gene (DNA) Mutations Substitution Deletion Insertion
Substitution
Deletion
Insertion