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Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats by Norbert Hübner, Reinhold Kreutz, Saori.

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Presentation on theme: "Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats by Norbert Hübner, Reinhold Kreutz, Saori."— Presentation transcript:

1 Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats by Norbert Hübner, Reinhold Kreutz, Saori Takahashi, Detlev Ganten, and Klaus Lindpaintner Hypertension Volume 26(2): August 1, 1995 Copyright © American Heart Association, Inc. All rights reserved.

2 Bar graphs show Ang II plasma concentrations in parental WKYHD and SHRSPHD (mean±SEM; n=24 in each group). Bar graphs show Ang II plasma concentrations in parental WKYHD and SHRSPHD (mean±SEM; n=24 in each group). Norbert Hübner et al. Hypertension. 1995;26: Copyright © American Heart Association, Inc. All rights reserved.

3 Schematic shows comparison of nucleotide and amino acid sequence between WKYHD and SHRSPHD. The bar represents the coding sequence of the angiotensinogen gene and indicates exonic structure as well as the site where Ang I is cleaved from the protein and its relation toward the Pvu II restriction fragment length polymorphism (RFLP) (C-to-T substitution at nucleotide position 495)11 and the molecular variant I154V (reflecting the A-to-G substitution at nucleotide position 513). Schematic shows comparison of nucleotide and amino acid sequence between WKYHD and SHRSPHD. The bar represents the coding sequence of the angiotensinogen gene and indicates exonic structure as well as the site where Ang I is cleaved from the protein and its relation toward the Pvu II restriction fragment length polymorphism (RFLP) (C-to-T substitution at nucleotide position 495)11 and the molecular variant I154V (reflecting the A-to-G substitution at nucleotide position 513). Norbert Hübner et al. Hypertension. 1995;26: Copyright © American Heart Association, Inc. All rights reserved.

4 Scatterplots show Ang II plasma concentrations against plasma renin activity before and after dietary sodium loading. Scatterplots show Ang II plasma concentrations against plasma renin activity before and after dietary sodium loading. Norbert Hübner et al. Hypertension. 1995;26: Copyright © American Heart Association, Inc. All rights reserved.

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