1. Yoshida Study Good day doctor/s!
First, let me thank you for giving me the opportunity to discuss with you another important topic that can be useful in your daily practice.
Today I would like to impart to you the role of Mucosta in synergism with proton-pump inhibitors in addressing the recurrence of GERD symptoms.

2. Recurrence rate of GERD
Proton pump inhibitors (PPIs) are effective in healing reflux esophagitis and relieving the symptoms of GERD as proven in various clinical trials, however GERD relapse and recurrence of symptoms during maintenance stage is observed.
The rate of recurrence of esophagitis with lansoprazole is reported to be about 10–30% with maintenance therapy over 24–48 weeks.
Ref) Yoshisa N. et al. Dig Dis Sci 2010; 55(12):

3. [Until recurrence of symptoms ]
YOSHIDA Study
II. Clinical study
Management of Recurrence of symptoms of Gastroesophageal Reflux Disease: Synergistic Effect of Rebamipide with 15mg Lansoprazole.
Methods
Study design : Open-label, two phase study (initial healing phase + randomized maintenance phase.
Objective : To investigate the effects of rebamipide, a mucosal protective anti-ulcer agent, on recurrence of reflux symptoms during PPI maintenance therapy.
Initial healing phase
Maintenance phase
Lansoprazole 15mg
Lansoprazole 30mg
or omeprazole 20mg
or rabeprazole 10mg
Patients who obtained symptomatic relief
(Less than 4 points on GSRS)
Randomization
With this, we wanted to show you the management of Recurrence of symptoms of Gastroesophageal Reflux Disease through Synergistic Effect of Rebamipide with 15mg Lansoprazole.
This is an Open-label, two phase study (initial healing phase + randomized maintenance phase)
Initial healing phase is Lansoprazole 30mg or omeprazole 20mg or rabeprazole 10mg. Patients who obtained symptomatic relief was randomized to either take Lanzoprazole or lanzoprazole + Rebamipide.
Lansoprazole 15mg + rebamipide 300mg
[ 8weeks ]
[ 12 months] or
[Until recurrence of symptoms ]
* Criteria for Recurrence :
Recurrence was define as patient report of recurrence of symptoms with a score of five points or higher on the GSRS questionnaire.
Ref) Yoshisa N. et al. Dig Dis Sci 2010; 55(12):

4. Yoshida Study II. Clinical study Results
Effect of rebamipide on PPI maintenance therapy
Group
Total patients
Relapse
within 12 months
Relapse rate (%)
Lansoprazole (15mg/day) 21 11
52.4*
+Rebamipide (300mg/day) 20 4
20.0*
Rebamipide in combination with PPI significantly decreased recurrence of symptoms in GERD patients
* P < 0,05, statistically significant
All recurrences in the lansoprazole 15mg group were noted within 6 months.
None of the patients reported any adverse effects during the study
Ref) Yoshisa N. et al. Dig Dis Sci 2010; 55(12):

5. Yoshida Study II. Clinical study Results
Results showed that IL-8 expression level in the esophageal mucosa of patients with rebamipide was significantly decreased compared with that of patients without rebamipide
Ref) Yoshisa N. et al. Dig Dis Sci 2010; 55(12):

6. Buy 25 tablets and get 15 tablets free
Patients buy 25 tablets to drugstores and keeps the receipt
Patient gets in touch OTSUKA ONE QUEST hotline:
Patient sends a copy of receipt to thru text /viber. OR
Patients mail the copy of the receipt to OTSUKA ONE QUEST.
OTSUKA ONEQUEST will send the free tablets to patients via mail
Let me remind you of Otsuka’s ONE QUEST patient program. Your patients can now enjoy bigger savings when they buy Rebamipide Mucosta.
For every purchase of 25 tablets, your patients can get free 15 tablets. They just have to keep the receipts and call the Otsuka ONE QUEST hotline for the details of the program.
ONE QUEST will immediately mail the free tablets to patient upon receipt of the proof of purchase.

7. Otsuka’S Novel Education for Quality, Efficacy and Safety
Good morning/afternoon/evening, Doctor!
I am very happy to inform you that we have just upgraded ONE Quest website.
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Just for a recap, ONE Quest, which stands for Otsuka’s Novel Education for Quality, Efficacy and Safety, is our holistic Patient Wellness Program which covers the entire treatment cycle from pre-treatment, diagnosis, to treatment and post treatment.
This time, we have enhanced our ONE Quest website to serve patients better, and...
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...to achieve Patient Well-being and foster patient Empowerment.

8. ONE Quest Website – New Features One with you in wellness
PATIENT
PROGRAMS
DISEASES
MD’S
CORNER
USER-FRIENDLY
INTERFACE
Here are the main features of our new ONE Quest website.
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1) PATIENT PROGRAMS
We provide updates on our patient program and patient support services at PATIENT PROGRAMS.
Patients can also find our upcoming event details and past event archives at NEWS & EVENTS and this will be regularly updated.
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2) DISEASES
To promote patients’ better understanding of health and diseases, we enhanced the DISEASES section per organ per disease, such as xxx under XXX and yyy under YYY (*see below for specific diseases). These answer basic questions on the disease(s) and provide health tips in easy-to-understand plain words.
*Brain – MDD, Bipolar, Schizophrenia, Stroke
*Heart – Congestive Heart Failure, Coronary Angioplasty
*Lungs – Asthma, Acute Bronchitis
*Stomach – Ulcer, Gastritis
*Liver – Cirrhosis, Hepatic Encephalopathy
*Others – PAD, Hyponatremia
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3) MD’S CORNER
Next is MD’S CORNER, which contains articles by doctors to help educate and empower patients.
We will be happy if you could also share your experience with us and patients in this portion.
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4) USER-FRIENDLY INTERFACE
To make it more user-friendly and for easy reading, our new ONE Quest website is designed to adjust itself to look good on all devices from desktop computers to smartphones. You don’t need to resize or scroll a lot to read the contents anymore.
We hope that all these new features will serve patients’ needs and benefit them.
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Doctor, Your patient is Our concern.
We are ONE with you in Patient Wellness with ONE Quest at
For any concerns on the website or program, our call center agents are ready to assist you.
Thank you very much for your time!
One with you in wellness