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UnTEThering (Smooth Muscle) Cell Plasticity

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Presentation on theme: "UnTEThering (Smooth Muscle) Cell Plasticity"— Presentation transcript:

1 UnTEThering (Smooth Muscle) Cell Plasticity
by Domenick A. Prosdocimo, Rajan Jain, and Mukesh K. Jain Circulation Volume 128(18): October 29, 2013 Copyright © American Heart Association, Inc. All rights reserved.

2 Ten-eleven translocation-2 (TET2) is an epigenetic regulator of vascular smooth muscle cell (VSMC) phenotype plasticity through a mechanism involving the oxidation of 5-methylcytosine (5-mC) and generation of 5-hydroxymethylcytosine (5-hmC). Ten-eleven translocation-2 (TET2) is an epigenetic regulator of vascular smooth muscle cell (VSMC) phenotype plasticity through a mechanism involving the oxidation of 5-methylcytosine (5-mC) and generation of 5-hydroxymethylcytosine (5-hmC). Myocd indicates Myocardin; and SRF, serum response factor. Domenick A. Prosdocimo et al. Circulation. 2013;128: Copyright © American Heart Association, Inc. All rights reserved.


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