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Biophysics of excitable cells

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Presentation on theme: "Biophysics of excitable cells"— Presentation transcript:

1 Biophysics of excitable cells
D. Braun / SS 2013 BPZ§4.1

2 Multiple exitatory and inhibitory synaptic contacts allow complex neuronal interconnects
H.Gaub / SS 2007 BPZ§4.1

3 Cell-Semiconductor-Hybrids: Neuron on the Chip
More: Fromherz MPI Martinsried D. Braun / SS 2013 BPZ§4.1

4 The electrical activity of neurons results from the opening and closing of specific ion-channels proteins in the neuron plasma membrane D. Braun / SS 2013 BPZ§4.1

5 Voltage-gated cation channels generate action potentials
D. Braun / SS 2013 BPZ§4.1

6 Membrane depolarizations spread passively only short distances
D. Braun / SS 2013 BPZ§4.1

7 Action potentials are propagated unidirectionally without diminution
Movements of only a few Na+ and K+ ions generate the action potential D. Braun / SS 2013 BPZ§4.1

8 Patch clamps permit measurement of ion movements through single channels
D. Braun / SS 2013 BPZ§4.1

9 Different patch clamping configurations
D. Braun / SS 2013 BPZ§4.1

10 Current flux through individual voltage-gated channels determined by patch clamping of muscle cells
D. Braun / SS 2013 BPZ§4.1

11 All five subunits in the nicotinic acetylcholine receptor contribute to the ion channel
D. Braun / SS 2013 BPZ§4.1

12 P segments form the ion-selectivity filter
D. Braun / SS 2013 BPZ§4.1


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