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Low-Flow Mediated Constriction is Endothelium-Dependent

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Presentation on theme: "Low-Flow Mediated Constriction is Endothelium-Dependent"— Presentation transcript:

1 Low-Flow Mediated Constriction is Endothelium-Dependent
by Ellen A. Dawson, Amr Alkarmi, Dick H.J. Thijssen, Sudhir Rathore, Diane E. Marsman, N. Timothy Cable, D. Jay Wright, and Daniel J. Green Circ Cardiovasc Interv Volume 5(5): October 16, 2012 Copyright © American Heart Association, Inc. All rights reserved.

2 Effect of catheterization on radial artery low-flow mediated vasoconstriction (L-FMC) and L-FMC+flow-mediated dilation (FMD). Effect of catheterization on radial artery low-flow mediated vasoconstriction (L-FMC) and L-FMC+flow-mediated dilation (FMD). Changes in L-FMC (%) (Upper panel) and L-FMC+FMD (Lower panel) in the catheterized (Cath) and noncatheterized (NoCath) arms (n=32). Data are before the procedure (Pre, solid bar) and the day after the procedure (Post, empty bar). Data are presented as mean±SE. 2-way GLM: L-FMC (time P=0.93, arm P=0.14 time×arm P=0.029), L-FMC+FMD (time P<0.001, arm P<0.001, time×arm P=0.001). *Post hoc t test significantly different pre to post P<0.05. †Post hoc t test significantly different from Cath arm. Ellen A. Dawson et al. Circ Cardiovasc Interv. 2012;5: Copyright © American Heart Association, Inc. All rights reserved.

3 Effect of postcatheterization exercise training on radial artery low-flow mediated vasoconstriction (L-FMC) and L-FMC+flow-mediated dilation (FMD). Effect of postcatheterization exercise training on radial artery low-flow mediated vasoconstriction (L-FMC) and L-FMC+flow-mediated dilation (FMD). Changes in L-FMC (%) (Upper panel) and L-FMC+FMD (Lower panel) in the intervention (exercise, n=9) and no exercise (control, n=9) groups. Data are before the procedure (Pre, solid bar) and 7 weeks postprocedure (Post, empty bar). Data are presented as mean±SE. 2-way GLM: L-FMC (time P=0.77, time×group P=0.05), L-FMC+FMD (time P=0.10, time×group P=0.009). *Post hoc t test significantly different pre to post P<0.05. †Significant interaction effect with 2-way GLM. Ellen A. Dawson et al. Circ Cardiovasc Interv. 2012;5: Copyright © American Heart Association, Inc. All rights reserved.


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