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Correlation Between the International Consensus Definition of the Cancer Anorexia- Cachexia Syndrome (CACS) and Patient-Centered Outcomes in Advanced Non-Small Cell Lung Cancer Thomas W. LeBlanc, MD, MA, Ryan D. Nipp, MD, Christel N. Rushing, MA, Greg P. Samsa, PhD, Susan C. Locke, PhD, Arif H. Kamal, MD, David F. Cella, PhD, Amy P. Abernethy, MD, PhD Journal of Pain and Symptom Management Volume 49, Issue 4, Pages (April 2015) DOI: /j.jpainsymman Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions
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Fig. 1 Study design and diagnosis definition consent. Inclusion criteria:15 1) weight loss greater than 50% over the past six months (in the absence of simple starvation); 2) body mass index less than 20 kg/m2 and any degree of weight loss greater than 2%; or 3) appendicular skeletal muscle index consistent with sarcopenia (males <7.26 kg/m2; females <5.45 kg/m2) and any degree of weight loss >2%. QOL = quality of life; PRO = patient-reported outcome; ECOG = Eastern Cooperative Oncology Group; FACT-G = Functional Assessment of Cancer Therapy-General; KPS = Karnofsky Performance Status; FACT-L = Functional Assessment of Cancer Therapy-Lung Cancer; FACT-F = Functional Assessment of Cancer Therapy-Fatigue; 6MWT = six-minute walk test; FAACT = Functional Assessment of Anorexia/Cachexia Treatment. Journal of Pain and Symptom Management , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions
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Fig. 2 Overall survival by CACS status. CACS = cancer anorexia-cachexia syndrome; HR = hazard ratio; OS = overall survival. Journal of Pain and Symptom Management , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions
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Fig. 3 Mean functional or quality of life scores (±SEM) by group and visit number. These plots are presented by visit number and not by actual calendar date. Thus, the plots are not directly comparable with the regression model statistics in Table 2. KPS = Karnofsky Performance Status; CACS = cancer anorexia-cachexia syndrome; ECOG = Eastern Cooperative Oncology Group; FACT-G = Functional Assessment of Cancer Therapy-General. Journal of Pain and Symptom Management , DOI: ( /j.jpainsymman ) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions
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