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Arterioscler Thromb Vasc Biol

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1 Arterioscler Thromb Vasc Biol
Lipolytically Modified Triglyceride-Enriched HDLs Are Rapidly Cleared From the Circulation by Shirya Rashid, P. Hugh R. Barrett, Kristine D. Uffelman, Takehiko Watanabe, Khosrow Adeli, and Gary F. Lewis Arterioscler Thromb Vasc Biol Volume 22(3): March 1, 2002 Copyright © American Heart Association, Inc. All rights reserved.

2 Figure 1. Comparison of die-away curves of HDL apoA-I (one representative animal for each group).
Figure 1. Comparison of die-away curves of HDL apoA-I (one representative animal for each group). A, Results for the TG-rich HDL+active HL (observed data, closed circles; modeled data, solid line) and TG-rich HDL+inactive HL tracers (observed data, open triangles; modeled data, dashed line) are shown. B, The decay curve for the TG-rich HDL+active HL tracer (observed data, closed circles; modeled data, solid line) is compared with the fasting (TG-poor) HDL+active HL tracer (observed data, open circles; modeled data, dashed line). The data presented on the y axis of both graphs represents the radioactivity on HDL-apoA-I isolated by gel electrophoresis of the delipidated HDL fraction (see Methods). The radioactivity data for each tracer was normalized as a function of the radioactivity measured at the first time interval (10 minutes). Shirya Rashid et al. Arterioscler Thromb Vasc Biol. 2002;22: Copyright © American Heart Association, Inc. All rights reserved.

3 Figure 2. Correlation between the %mass of TG in HDL and the HDL apoA-I FCR. A strong positive correlation was observed between HDL TG content and apoA-I FCR in the combined TG-rich HDL+active HL and fasting (TG-poor) HDL+active HL groups (R=0.59, P<0.05). Figure 2. Correlation between the %mass of TG in HDL and the HDL apoA-I FCR. A strong positive correlation was observed between HDL TG content and apoA-I FCR in the combined TG-rich HDL+active HL and fasting (TG-poor) HDL+active HL groups (R=0.59, P<0.05). Note that only the two groups in which active HL was incubated with HDL were included in this analysis (n=12). Shirya Rashid et al. Arterioscler Thromb Vasc Biol. 2002;22: Copyright © American Heart Association, Inc. All rights reserved.


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