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Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression in an Lck-dependent manner. Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression.

Published byMarianne Christiansen Modified over 6 years ago

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Presentation on theme: "Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression in an Lck-dependent manner. Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression."— Presentation transcript:

1 Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression in an Lck-dependent manner.
Rab11-FIP3 silencing upregulates TCR-CD3 cell surface expression in an Lck-dependent manner. (A) Jurkat T cells were transfected with two-by-two combinations of control, Lck, and FIP3.1 siRNA oligonucleotides. CD3 cell surface expression was then assessed by flow cytometry. Measurements are expressed as percentage of staining of cells transfected with control siRNA. Mean of triplicates ± SD, Mann–Whitney U test. Representative of three experiments. (B) FIP3 protein expression was analyzed by Western blot with respect to a nonspecific band of 37 kDa, used here as a loading control. ***p < 0.001, n.s.p ≥ 0.05. Jérôme Bouchet et al. J Immunol 2017;198: Copyright © 2017 by The American Association of Immunologists, Inc.

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