3. Burden of Atrial Fibrillation

4. The Percentage of Strokes Attributable to AF Increases With Age

5. Unmet Needs in Managing Elderly With AF

6. Issues of OAC in the Elderly

9. Efficacy and Safety of NOACs Pre-specified Meta-analysis of all 71,683 Patients

10. Efficacy vs Safety NOAC 4-trial Meta-analysis Full Dose

12. Ethnic Differences in Rate of ICH

13. NOAC Antidotes in Clinical Trials

17. NOAC Dose Reduction

18. Summary

19. Abbreviations

20. Abbreviations (cont)

21. Abbreviations (cont)

22. References

23. References (cont)

24. References (cont)

25. References (cont)

26. References (cont)