1. Exploring the Structure of DNA Research-Based, Interdisciplinary STEM Education (RISE)

2. Today’s Agenda: The Discovery of the Structure of DNA
Parts of the DNA Molecule
Important Bonds in DNA
Double Helix Structure
DNA Function
Exploring Epigenetics and Methylation
Seminar

3. Discovering the Structure of DNA:

5. Part 1: Parts of the DNA Molecule

7. Part 2: Linking the Parts Together Through Chemical Bonds

8. The Phosphodiester Bond

9. Part 3: Exploring Hydrogen Bonding
Electrostatic attraction between hydrogen atoms bonded to small, strongly electronegative atoms (N, O and F) and the lone pair electrons on these electronegative atoms.

10. Part 3: Hydrogen Bonding

11. Part 4: Double Helix

12. Part 5: DNA Function
When does DNA replicate? Are you replicating any DNA right now?
What’s important about this process?

13. DNA Replication:

14. DNA Replication: Let’s Watch

15. Epigenetics and DNA Methylation:
Do all your cells have the same DNA?
Do all your cells use all their DNA? Why or why not?

16. Epigenetics and DNA Methylation:
Differential gene expression allows different cell types to adopt different fates.
Mistakes in gene regulation are associated with a variety of diseases, especially cancer.

17. DNA Methylation: This reaction is enzyme-mediated.
DNA methylation silences genes by causing the DNA to condense.

18. DNA Methylation: Let’s Watch

19. How do we detect DNA methylation?
We use CHEMISTRY!

20. How do we detect DNA methylation?
We use CHEMISTRY!

21. Next: Your Seminar Find your team! Introductions and Roles.
Discuss the paper, using your questions as a guide.
Report out!

22. Structure, Function, and the Value of Visualization: