1. 1224 STEMI pts, no reperfusion, < 24 hours from onset
Treatment with Enoxaparin and Tirofiban in acute MI (TETAMI) M.Cohen et al, Beth Israel Hospital, NJ
1224 STEMI pts, no reperfusion, < 24 hours from onset
4 treatment groups
Enox 30 mg iv plus 1 mg/Kg sc bd alone
Enox 30 mg iv plus 1 mg/Kg sc bd with Aggrastat 100 ug/Kg IV
UFH 70 U/Kg plus 15 U/Kg per hour infusion
UFH 70 U/Kg plus 15 U/Kg inf. with Aggrastat 100 ug/Kg IV
Subgroup analysis showed protective Tirofiban trend in:
Pts treated within 12 hours
LV dysfunction
Study underpowerd for mortality

2. Outcomes in TETAMI End points (all 30 days) Enoxaparin
AHA 2002 review
Outcomes in TETAMI
End points (all 30 days)
Enoxaparin
Enoxaparin + tirofiban
UFH
UFH + tirofiban
Randomized patients
n=229
n=305
n=306
n=314
Death/
recurrent MI/
recurrent angina
15.4%
16.1%
17.3%
17.2%
recurrent MI
8.7%
8.5%
9.2%
8.0%
Treated patients
n=297
n=303
n=310
Major hemorrhage
1.0%
2.0%
1.6%
Hemorrh. stroke
0.0%
0.3%
Cohen M. American Heart Association Scientific Sessions 2002.