1. Chapter 15 – The Chromosomal Basis of Inheritance

2. Sex Determination

3. Sex-linked genes

4. Sex linked inheritance
Must show sex chromosomes
Hemizygous

5. X inactivation
Barr body

6. Linked genes

7. Nondisjunction
Aneuploidy
Monosomy
Trisomy

8. Down syndrome

9. Trisomies in sex chromosomes
Klinefelter syndrome 47, XXY
Jacob syndrome 47, XYY
TriploX 47, XXX

10. Monosomy in sex chromosome
Turner syndrome 45, XO

11. Chromosome structural abnormalities
Deletion
Duplication

12. Chromosome structural abnormalities cont
Inversion
Translocation