1. A B C D E F WT Simulation WT
P2/P1
WT Simulation
P1-P2 interval (ms) B WT
Veldkamp et al Circ. Res. 86:e91-97 C
Kambouris et al JCI. 105: WT D
Rivolta et al JBC. 276(33): WT
Recovery time (ms) E
Wehrens et al Circulation. 102:584-90 WT F
Abriel et al Circ. Res. 88:740-5 WT
Supplemental Figure 1

2. Membrane potential (mV)
activation
availability
Availability/conductance
WT simulation
Membrane potential (mV) B WT
Chandra, Starmer and Grant AJP H C WT
Abriel et. al Circ. Res. 88: D WT
Wehrens et. al Circulation. 102:
See also Rook et.al Cardiovascular Res
Makita et. al Circulation. 101:54-60.
Rivolta et. al JBC
Supplemental Figure 2