1. Volume 150, Issue 6, Pages 1281-1290 (December 2016)
Measuring Airway Remodeling in Patients With Different COPD Staging Using Endobronchial Optical Coherence Tomography 
Ming Ding, PhD, Yu Chen, PhD, Wei-Jie Guan, PhD, Chang-Hao Zhong, MD, Mei Jiang, MD, Wei-Zhan Luo, MD, Xiao-Bo Chen, MD, Chun-Li Tang, MD, Yan Tang, MD, Qi-Ming Jian, MD, Wei Wang, MD, Shi-Yue Li, MD, Nan-Shan Zhong, MD 
CHEST 
Volume 150, Issue 6, Pages (December 2016)
DOI: /j.chest
Copyright © 2016 American College of Chest Physicians Terms and Conditions

2. Figure 1
Cross-sectional images of endobronchial optical coherence tomography (EB-OCT) in the (A) fifth-, (B) seventh-, and (C) ninth-generation bronchi. Compared with never-smokers (A1, B1, C1), stage III-IV in patients with COPD is characterized by the most significant mucosal thickening and blurred submucosal layer (A3, B3, C3), followed by heavy smokers with normal FEV1 (SNL) (A2, B2, C2).
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Copyright © 2016 American College of Chest Physicians Terms and Conditions

3. Figure 2
Longitudinal EB-OCT images demonstrating the morphologic differences of a never-smoker, SNL, and a patient with stage III COPD. Tapering of the inner airway lumen is most significant in (C) COPD (stage III, followed by (A) never-smokers and (B) SNL. See Figure 1 legend for expansion of abbreviations.
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Copyright © 2016 American College of Chest Physicians Terms and Conditions

4. Figure 3
Trends in tapering of EB-OCT parameters of each generation of bronchi among never-smokers, SNL, and patients with COPD. (A) The Ai7 of stage II COPD is smaller than that of stage I COPD (P = .017) but greater than that of stage III-IV COPD (P = .003). (B) Similar trend of changes seen in A. The dashed line indicates an inner airway diameter of 2 mm. * Indicates that the among-group differences are statistically significant. (C) # Indicates no significant difference between SNL and patients with COPD and among various stages of COPD (all P > .05). SNL present with greater airway wall thickness than do never-smokers in the seventh-, eighth-, and ninth-generation bronchi (all P < .001). GOLD = Global Initiative for Lung Disease. See Figure 1 legend for expansion of other abbreviations.
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5. Figure 4
Correlation between FEV1% predicted and Ai3-6, Ai7-9 and Aw3-6, Aw7-9. (A and B) Ai3-6 and Ai7-9 are significantly correlated with FEV1% predicted (r = 0.731; P < .001 and r = 0.768; P < .001). (C and D) Correlation is significant between Aw3-6 and FEV1% predicted (r = –0.591; P < .001) but not in Aw7-9 (r = 0.069; P = .575). Dashed lines correspond to COPD staging (ie, FEV1% predicted = 30%, 50%, and 80%). Aw = airway wall area. See Figure 3 legend for expansion of other abbreviations.
CHEST  , DOI: ( /j.chest )
Copyright © 2016 American College of Chest Physicians Terms and Conditions