1. Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface.
Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface. (A) Surface representation of the TGF‐β3 homodimer bound to the TβRI and TβRII extracellular domains (PDB 2PJY). The two protomers of TGF‐β3 are depicted in magenta and blue, TβRII in green, and TβRI in yellow. C‐terminal residues of the receptor extracellular domains are shaded grey. Distances between the C‐terminal residues of the receptor extracellular domains are shown on the projection onto the cell surface. Circled numbers correspond to the number of amino acids between the last structurally ordered residue in receptor extracellular domain and the first predicted residue of the transmembrane domain. (B) Surface representation of the BMP‐2 homodimer bound to the BMPRIa and ActRII extracellular domains (PDB 2GOO) shown in a similar manner to the TGF‐β complex in panel (A). The two protomers of BMP‐2 are depicted in orange and brown, ActRII in magenta, and BMPRIa in cyan.
Tao Huang et al. EMBO J. 2011;30:
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