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Nat. Rev. Clin. Oncol. doi: /nrclinonc

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Presentation on theme: "Nat. Rev. Clin. Oncol. doi: /nrclinonc"— Presentation transcript:

1 Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2016.79
Figure 3 Regulatory considerations in trial development of drugs combined with radiotherapy Figure 3 | Regulatory considerations in trial development of drugs combined with radiotherapy. Early interactions with regulatory agencies are recommended because of the limited published regulatory guidance. CHMP, Committee for Medicinal Products for Human Use; EMA, European Medicines Agency; IND, investigational new drug; MOA, mechanism of action; MTD, maximum tolerated dose; NDA, new drug application; PI/PII/PIII, phase of development of clinical trial; RT, radiotherapy. Sharma, R. A. et. al. (2016) Clinical development of new drug–radiotherapy combinations Nat. Rev. Clin. Oncol. doi: /nrclinonc

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Nat. Rev. Clin. Oncol. doi: /nrclinonc

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Figure 2 Underreporting by physicians of specific treatment-associated symptoms by physicians in the TORCH trial Figure 2 | Underreporting by physicians.

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Figure 1 Concept of the therapeutic index

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Figure 4 Example of PK/PD simulation to optimize a vinorelbine treatment regimen Figure 4 | Example of PK/PD simulation to optimize a vinorelbine treatment.

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Figure 2 Multiscale modelling in oncology

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Figure 5 Schematic illustration of different clinical trial designs

Figure 5 Schematic illustration of different clinical trial designs
Nat. Rev. Clin. Oncol. doi: /nrclinonc

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Figure 1 Generations of cancer vaccine antigens

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Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Figure 1 Key time points in the discovery and development of imatinib for the treatment of chronic myeloid leukaemia (CML) and gastrointestinal stromal.

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Nat. Rev. Cardiol. doi: /nrcardio

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Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Figure 2 Copy-number variations in multiple myeloma

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Figure 5 Identification of mucinous carcinoma

Figure 5 Identification of mucinous carcinoma
Figure 1 Underreporting of treatment-related toxicities by physicians, relative to patients with either advanced-stage lung cancer, or early-stage breast.

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Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
Figure 2 Therapeutic targeting of the PI3K/AKT/mTOR pathway

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