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Voltage-gated ion channels

Published bySuparman Lesmono Modified over 6 years ago

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Presentation on theme: "Voltage-gated ion channels"— Presentation transcript:

1 Voltage-gated ion channels

2

3 Purifyinf ryanodine receptors

4 Purifying ryanodine receptors

5 Recording ryanodine receptors in planar lipid bilayers

6 Ryanodine receptor single channel currents

7 Ryanodine receptor single channel currents

8 Ryanodine receptor single channel currents

9 Regulation of EC coupling by adrenergic signaling -- “fight or flight”

10 RyR2 macromolecular complex

11 RyR macromolecular complexes are leucine/isoleucine zippers
held together by leucine/isoleucine zippers

12 RyR2/calcium release channel phosphorylated by addition of cAMP alone

13

14 PKA phosphorylation activates RyR2 and induces subconductance states

15 Dependence of ryanodine receptor conductance on luminal calcium concentration

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