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P.W. Kalivas, N. Volkow, J. Seamans  Neuron 

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Presentation on theme: "P.W. Kalivas, N. Volkow, J. Seamans  Neuron "— Presentation transcript:

1 Unmanageable Motivation in Addiction: A Pathology in Prefrontal-Accumbens Glutamate Transmission 
P.W. Kalivas, N. Volkow, J. Seamans  Neuron  Volume 45, Issue 5, Pages (March 2005) DOI: /j.neuron Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Cellular Adaptations in the PFC-Accumbens Projection that May Underlie the Cardinal Characteristics of Addiction Cell signaling, changes induced by dopamine receptor signaling in ion channel conductances regulating cell excitability (see Seamans and Yang, 2004, for detailed description); iGluR, ionotropic glutamate receptor; mGluR, metabotropic glutamate receptor. The size of symbols or lettering connotes increases or decreases following withdrawal from cocaine. Neuron  , DOI: ( /j.neuron ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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