1. Schizophrenia Drug therapy – typical and atypical antipsychotics

2. TREATMENT FOR SCHIZOPHRENIA
Historically people suffering from mental health issues were not treated with dignity or respect.

3. Before 50s schizophrenia was considered untreatable and patients were interned in mental institutions

4. Over time there have been a variety of different methods to treat schizophrenia

5. Rosenhan & Seligman vividly explain the back wards of mental hospitals as ‘snake pits’, filled with inmates who were unreachable or mutely catatonic, or were wild with delusions and straitjacketed.
Attempts to treat schizophrenia such as insulin shock, ECT and drugs had failed.

6. Chemotherapy
Since 50s use of drugs to treat mental disorders is widespread
Types of drugs fall into following categories
Anti-anxiety
Anti-depressant
Anti-psychotic
Anti-manic
Stimulants
They work to either increase or reduce the levels of neurotransmitters

7. Lets remind ourselves of the Dopamine Hypothesis:
Group poster activity
Lets remind ourselves of the Dopamine Hypothesis:
Use this to propose how you could design a Drug Therapy

8. DISCOVERY
In mid 1950s discovered that large daily doses of Amphetamines could produce a psychosis identical to schizophrenia
Amphetamine increases D2 transmission
Chlorpromazine improves symptoms of schizophrenia
Prevents Dopamine from activating
This knowledge has led to the development of drugs that have similar pharmacological properties to chlorpromazine.
The symptoms that are most responsive to these types of drugs are the ‘positive’ symptoms.

9. “Problem Schizophrenics”
Newer generation antipsychotics can be effective in these normally unresponsive schizophrenics. They also lack some of the debilitating side effects of the older Drugs.
These newer generation antipsychotics appear to block multiple subtypes of dopamine receptors (including D1 D2 D3 D4 D5).

10. Prep Activity You will each be allocated a drug to research.
Using this information, construct an anti psychotic drug package.
You must include:
the mode of action of the drug
side effects
appropriateness
You must include health warning / side effects information on your packet.

11. Evaluation of biological treatments