1. Overweight and Obesity: Validation as a Chronic Disease

2. Overweight and Obesity Is Currently Defined Based Upon BMI

3. BMI: Advantages

4. BMI: Disadvantages

5. Definition of “Disease”

6. Adiposopathy: Summary

7. Adiposopathy: Summary (cont)

8. Adiposopathy: Summary (cont)

9. Obesity Treatment Recommendations

10. Patient-centered Approaches to the Management of Obesity

11. Historical View of Obesity

12. Current Perspective of Obesity

13. Obesity: A Failure of Weight Regulation

14. Macroenvironmental Influences*

15. Microenvironmental Influences*

16. Composition of Popular Diets

17. Physical Activity Extends Weight Loss: Look AHEAD Trial

18. Effects of Chronic Exercise

19. Practical Guidance: Embrace Modest Weight Loss

20. Practical Guidance: Go Slow and Try Different Approaches

21. The 5As for Obesity Management

22. The 5As of Obesity Management

23. Ask

24. Assess

25. The 4Ms of Obesity

26. Advise

27. Advise (cont)

28. Agree

29. Assist

30. Putting It All Together

31. Managing Patients Who Are Obese: Using a Multidisciplinary Team and Multifaceted Approach

32. Strategies to Improve a Multidisciplinary Team Approach

33. What to Assess?

34. Multifaceted Approach to a Multifaceted Problem

35. Approaches to Weight Management

36. Macronutrient Proportion and Body Weight in Adults

37. Taking the Next Step

38. Pharmacotherapy for the Management of Obesity

39. Hormonal and Neural Pathways Regulate Food Intake and Body-Fat Mass

40. Hypothetical “Feed-forward” Positive Feedback Mechanism to Drive Weight Up

41. Anti-Obesity Drugs and Their Complex Pathways

42. The Problem

43. Newly Approved and Investigational Anti-Obesity Medications

44. Safety Information

45. Safety Information (cont)

46. Bringing it All Together: Recipe for an Effective Weight Loss Plan

47. Obesity Is a Complex Disease With Multiple Determinants

48. There Are Multiple Options for Obesity Treatment

49. Current Hierarchical Provision of Obesity Care by Physicians

50. Applying the Modified 5As for Obesity Management

51. Alternative Strategy Ask. Advise. Refer. = 5As

52. New Hierarchical Provision of Obesity Care by Physicians

53. Patient Encounter

54. Intensification of Therapies to Achieve Weight Loss Goals

55. Take Home Tips

56. Abbreviations

57. Abbreviations (cont)

58. References

59. References (cont)

60. References (cont)

61. References (cont)

62. References (cont)