1. Out of the Periphery and Into Comprehensive Care: Managing Diabetic Peripheral Neuropathy

2. Program Goals

3. Standards of Care: Comprehensive Annual Foot Examination

4. Goals of Treatment

5. Trends in Lower Extremity Amputation in Patients With Diabetes

6. Symptoms and Signs of DPN

7. Diagnostic Tools for DPN: Large-fiber

8. Diagnosis of DPN (cont)

9. Distribution of DPN

10. Atrophy of Leg Muscles

11. “Take Off Your Shoes”

12. Risk Factors for DPN

13. Treatment of DPN

14. Challenges With Current Treatments

15. Biochemical Vitamin B12 Deficiency (≤ 148 pmol/L)

16. Homocysteine

17. Medical Food

18. Metanx®

19. Evaluation of Metanx on DPN in Zucker Diabetic Fatty Rats

25. Closing Comments

26. Abbreviations

27. References

28. References (cont)

29. References (cont)

30. References (cont)

31. References (cont)

32. References (cont)

33. References (cont)

34. References (cont)

35. References (cont)

36. References (cont)