1. Page 1 Protein Ubiquitinylation — Creative BioMart

2. Page 2 As a leading biotechnology services supplier, Creative BioMart offers protein ubiquitinylation services. With our expertise as a leader in the field of ubiquitinylation services, Creative BioMart has created a set of new platform technologies.Creative BioMart

3. Page 3 Creative BioMart provides compound screening and profiling against E3 ligase cascades. Each ubiquitination cascade consists of the three enzyme components (E1 activating enzyme, E2 conjugating enzyme and E3 ligase), plus a biologically-relevant substrate. The incorporation of ubiquitin into the substrate is quantitatively detected by electrochemiluminescence, which allows for the identification of compound inhibitors and activators.

4. Page 4 Highlights Validated assays for an expanding panel of E3 ligase cascades to screen and profile inhibitors and enhancers. Cascades consist of E1, E2 and E3 enzymes and substrates. Uses biologically relevant substrate. Single or multiple concentration. Run by the same experts who have run many years experience.

5. Page 5 Ubiquitin E3 Ligase Identification Service Creative BioMart employs a high-content microarray and ubiquitin pathway expertise to identify candidate E3's that are capable of ubiquitylating your substrate

6. Page 6 The service includes the following steps: A high-content, functional microarray is probed with client's substrate. Probe microarray with antibody to client's substrate or associated tag. Direct labeling of the protein is available for detection. Locations of substrate binding indicate E3-substrate interactions and potential E3 enzymes that ubiquitylate client's substrate.

7. Page 7 About Creative BioMart Starting from a small supplier of proteins and enzymes for academic institutes and biotech companies, Creative BioMart has always been focusing on developing high quality protein products including recombinant protein, GMP proteins, native proteins, assay kit, etc. and efficient protein service. Over the past decade, our products and services are proved to have served our customers well and our brand has become one of the most trustworthy in the market.GMP proteins

8. Page 8 Thanks for watching! Contact Creative BioMart Address: 45-1 Ramsey Road Shirley, NY 11967, USA Email: contact@creative-biomart.com Website: http://www.creativebiomart.net