Presentation is loading. Please wait.

Presentation is loading. Please wait.

دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University.

Published by Modified over 6 years ago

Similar presentations

Presentation on theme: "دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University."— Presentation transcript:

1 دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University

2 CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH 2 mole Pyruvic acid 2 mole Acetyl CoA

3 CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH 2 mole Pyruvic acid 2 mole Acetyl CoA

4 CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CHO (HCOH) 4 CH2OH Glucose + 6 C 3+3 C 2+2 C C 6 H 12 O 6 C6H8O6C6H8O6C6H8O6C6H8O6 C4H6O2C4H6O2C4H6O2C4H6O2 - 4 H - 2 H - 4 O

5 CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CH 3 C = O COOH CH 3 C = O SCoA Dehydrogenase NAD NADH 2 Decarboxylase CO 2 CoASH Pyruvic acid Acetyl CoA CHO (HCOH) 4 CH2OH Glucose + 6 C 3+3 C 2+2 C C 6 H 12 O 6 C6H8O6C6H8O6C6H8O6C6H8O6 C4H6O2C4H6O2C4H6O2C4H6O2 - 4 H - 2 H - 4 O

6 CO 2 دورة كريبس من حيث ذرات الكربون

7 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

8 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

9 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

10 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4 2 C 4 C 6 C 5 C 4 C

11 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4 حمض الستريك حمض السكسنيك حمض فوماريك حمض ماليك

12 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4 دورة الأحماض ثلاثية الكربوكسيل

13 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

14 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4 عدد مولات ATP الناتجة خلال دورة كريبس = 4 × 3 = 12 ولكن لدينا 2 مول بيروفيك من 1 جلوكوز وبالتالي = 12 × 2 = 24 مول ATP عدد مولات ATP الناتجة خلال دورة كريبس = 4 × 3 = 12 ولكن لدينا 2 مول بيروفيك من 1 جلوكوز وبالتالي = 12 × 2 = 24 مول ATP

15 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

16 CH 3 C = O SCoA CH 2 - COOH C- COOH O = Oxal acetic Acetyl CoA HOH Inolase OH CH 2 - COOH C- COOH O OH - CH 2 - COOH CoASH Citric acid Inolase HOH CH 2 - COOH C- COOH CH- COOH Inolase CH 2 - COOH CH- COOH HOCH- COOH Akontic acid Iso-citric acid Dehydrogenase NAD NADH 2 CH 2 - COOH CH- COOH O=C- COOH Oxal succinic α-Keto glutaric CH 2 - COOH CH 2 O=C- COOH Decarboxylase CO 2 HOH CH 2 - COOH CH 2 O=C- SCoA Succinyl CoA NAD NADH 2 CO 2 CoASH HOH CoASH CH 2 - COOH Succinic acid CH - COOH Fumaric acid CH 2 - COOH HOCH - COOH Malic acid HOH NAD NADH 2 NAD NADH 2 1 2 3 4

17 جلوكوز بيروفيك استيل كو أ 8 ATP 3ATP 38 ATP 3ATP كريبس. 12ATP

Download ppt "دورة كريبس Dr. Zelal Alsaftli Animal Production Department Agriculture College Hama University."

Similar presentations

Acetyl-COA 1 Citric acid KREBS CYCLE Oxaloacetic acid C C C C C OOH C CoA C O H3CH3C C C C C OOH.

Acetyl-COA 1 Citric acid KREBS CYCLE Oxaloacetic acid C C C C C OOH C CoA C O H3CH3C C C C C OOH.
Of aerobic and anaerobic metabolism during sports

Of aerobic and anaerobic metabolism during sports
Link Reaction Link Reaction and The Citric Acid Cycle.

Link Reaction Link Reaction and The Citric Acid Cycle.
THE KREB’S CYCLE What Goes Around Comes Around. The Krebs Cycle The Krebs Cycle What Goes Around Comes Around Part 1: Preparation of Pyruvate Pyruvate.

THE KREB’S CYCLE What Goes Around Comes Around. The Krebs Cycle The Krebs Cycle What Goes Around Comes Around Part 1: Preparation of Pyruvate Pyruvate.
EL CATABOLISMO. GLUCOSA F 2 NADH + 2H + 2 NAD + 2 ADP 2 ATP F.

EL CATABOLISMO. GLUCOSA F 2 NADH + 2H + 2 NAD + 2 ADP 2 ATP F.
EL CATABOLISMO. GLUCOSA 2 ÁCIDO PIRÚVICO (3C) 2 NADH + 2H + 2 NAD + 2 ADP 2 ATP.

EL CATABOLISMO. GLUCOSA 2 ÁCIDO PIRÚVICO (3C) 2 NADH + 2H + 2 NAD + 2 ADP 2 ATP.
When glucose enters a cell, a phosphate group (from ATP) gets attached to C #6. Phosphorylation C 6 H 12 O 6 + PO 4  glucose-6-phosphate.

When glucose enters a cell, a phosphate group (from ATP) gets attached to C #6. Phosphorylation C 6 H 12 O 6 + PO 4  glucose-6-phosphate.
Three Fates of Pyruvate Pyruvate  acetyl-CoA Occurs in mitochondria Produce CO 2 and NADH + H + Pyruvate Dehydrogenase Aerobic **Acetyl-CoA used in the.

Three Fates of Pyruvate Pyruvate  acetyl-CoA Occurs in mitochondria Produce CO 2 and NADH + H + Pyruvate Dehydrogenase Aerobic **Acetyl-CoA used in the.
PYRUVATE DEHYDROGENASE/

PYRUVATE DEHYDROGENASE/
Citric Acid Cycle (C.A.C.). Mitochondrial Structure (cont.)

Citric Acid Cycle (C.A.C.). Mitochondrial Structure (cont.)
1 24.1The Citric Acid Cycle Chapter 24 Metabolism and Energy Production.

1 24.1The Citric Acid Cycle Chapter 24 Metabolism and Energy Production.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 18 Metabolic.

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 18 Metabolic.
Pre-Krebs and Krebs Cycle

Pre-Krebs and Krebs Cycle
Chapter 16.1: Production of Acetyl-CoA CHEM 7784 Biochemistry Professor Bensley.

Chapter 16.1: Production of Acetyl-CoA CHEM 7784 Biochemistry Professor Bensley.
Chapter 16.2: The Citric Acid Cycle CHEM 7784 Biochemistry Professor Bensley.

Chapter 16.2: The Citric Acid Cycle CHEM 7784 Biochemistry Professor Bensley.
Oxidative Decarboxylation of pyruvate and TCA cycle

Oxidative Decarboxylation of pyruvate and TCA cycle
Recap of Fermentations Glucose -> 2 pyruvate + 2 ATP + 2 NADH 2 pyruvate + 2 NADH -> 2 lactate 2 pyruvate + 2 NADH -> 2 ethanol + 2 CO 2 First part of.

Recap of Fermentations Glucose -> 2 pyruvate + 2 ATP + 2 NADH 2 pyruvate + 2 NADH -> 2 lactate 2 pyruvate + 2 NADH -> 2 ethanol + 2 CO 2 First part of.
Metabolism and Energy Production

Metabolism and Energy Production
Essential Knowledge 2.A.2: Organisms capture and store free energy for use in biological processes.

Essential Knowledge 2.A.2: Organisms capture and store free energy for use in biological processes.
MOLECULES IN METABOLISM. Metabolic Chemistry Related to Overweight Reactions and molecules in the digestive process.

MOLECULES IN METABOLISM. Metabolic Chemistry Related to Overweight Reactions and molecules in the digestive process.

Similar presentations

Ads by Google