1. Updates in Acute PE Treatment

3. Program Goals

4. Pulmonary Embolism Scope of the Problem

5. Massive vs Submassive PE

6. Risk Stratification of Acute PE

7. Ultrasound-Accelerated Thrombolysis EkoSonic® Endovascular System

8. USAT Mechanism of Action

9. SEATTLE II Study Overview

10. SEATTLE II Study Outcomes

11. Case Study 1

12. CT Scan Extensive Bilateral PE

13. CT Scan RV/LV Ratio = 2.5

14. Jugular Approach PAP 59/18 (Mean 32 mm Hg)

15. Catheterization Special Considerations

16. Cardiac Imaging 90 Minutes Post-Infusion

17. Improvement in Vitals Post-USAT

18. Pre- and Post-USAT: 48 Hours

19. Follow-Up

20. OPTALYSE-PE Study Design

21. OPTALYSE-PE Overall Results

22. Case Study II

23. Saddle PE

24. Increased RV/LV Ratio = 1.7

25. Catheterization Results

26. Outcomes and Follow Up

27. Raising Awareness Within Medical Community About USAT

28. Take-Home Messages

29. Abbreviations

30. Abbreviations (cont)