1. Selection of NSAIDs for Osteoarthritis

2. NSAID Use in United States

3. NSAID Use on the Rise in the United States

4. Osteoarthritis

5. NSAID Use and Selection Important Considerations

6. Assessment for NSAID GI Toxicity Risk 2009 ACG Guidelines

7. Cumulative Incidence of a Confirmed Upper Gastrointestinal Event

8. VIGOR: High-Dose Rofecoxib Increases CV Events*

9. CNT: Effects of Coxib Therapy on Major Vascular Events and Heart Failure

10. CNT: Relative Risk for Major Vascular Events, Traditional NSAIDs

11. 2009 American College of Gastroenterology Guidelines Prevention of NSAID-Related Ulcer Complications

12. Variables Determining NSAID CV Risk

13. Cyclooxygenase

14. COX-inhibitor Effects

15. Variables Determining NSAID CV Risk

16. NSAIDs Interaction with Low-Dose Aspirin

17. Naproxen and Low Dose Aspirin

18. FDA Strengthens NSAID CV Warning

19. The PRECISION Trial

20. Common Primary Care Scenarios

21. Common Primary Care Scenarios Polypharmacy Safeguards

22. Summary

23. Abbreviations

24. Abbreviations (cont)