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Hydrogels / Applications in Opthamology
Frequently, presenters must deliver material of a technical nature to an audience unfamiliar with the topic or vocabulary. The material may be complex or heavy with detail. To present technical material effectively, use the following guidelines from Dale Carnegie Training®. Consider the amount of time available and prepare to organize your material. Narrow your topic. Divide your presentation into clear segments. Follow a logical progression. Maintain your focus throughout. Close the presentation with a summary, repetition of the key steps, or a logical conclusion. Keep your audience in mind at all times. For example, be sure data is clear and information is relevant. Keep the level of detail and vocabulary appropriate for the audience. Use visuals to support key points or steps. Keep alert to the needs of your listeners, and you will have a more receptive audience. 11/6/2018
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Polyelectrolyte Hydrogels
Hydrophilic polymer chains containing positive or negatively charged functional groups that interact electrostatic interactions to form a cross-linked network that attracts water 11/6/2018
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Hylauronic Acid 11/6/2018
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Polyelectrolyte Multilayers
Layer by layer deposition 11/6/2018
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Alginate gels 11/6/2018
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Enzyme Immobilization
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Cell Encapsulation 11/6/2018
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Alginate gels 11/6/2018
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Alginate gels 11/6/2018
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Applications artificial tendon and cartilage
wound healing dressings (Vigilon®, Hydron®, Gelperm®) non-antigenic, flexible wound cover permeable to water and metabolites low-strength artificial kidney membranes artificial skin maxillofacial and sexual organ reconstruction materials vocal cord replacement 11/6/2018
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Corning® Ultra Low Attachment Products Unique hydrogel surface inhibits cell attachment
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Hydrogels: Applications
Earliest biomedical application contact lenses good mechanical stability favorable refractive index high oxygen permeability needs hygienic maintenance unable to correct for astigmatism 11/6/2018
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Acrylates 11/6/2018
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Methacrylates 11/6/2018
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Poly(methyl methacrylate)
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Poly(2-hydroxyethylmethacrylate pHEMA
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Hydrogels: PHEMA The most widely used hydrogel
water content similar to living tissues inert to biological processes shows resistance to degradation permeable to metabolites not absorbed by the body withstands sterilization by heat prepared in various shaped and forms 11/6/2018
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Contact lens PMMA HEMA Fabrication methods
Computer assisted cutting (lathe)-PMMA rods Spin casting-polymerization Molding-polymerization 11/6/2018
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Intraocular lens PMMA HEMA
Polymer backbone - mixture of PMMA and PHEMA Varying water contents Additives such as UV blockers 11/6/2018
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Foldable IOL complications/explantations -
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Reasons for Revision Surgery
Incorrect lens power seen most commonly Glare/optical aberrations Dislocation/decentration Late postoperative opacification 11/6/2018
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IOL Optic Opacification
Surface opacification Opacification within the substance of the optic Analysis of opacifications reveals presence of calcium Calcium staining Scanning electron microscopic analysis 11/6/2018
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Accommodative IOL: 1CU (HumanOptics)
Total diameter: 9.7 mm 11/6/2018
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