1. Innate Immunity
Hugh B.
Fackrell

2. Innate Immunity Assigned Reading Content Outline
Performance Objectives
Key terms
Key Concepts
Short Answer Questions
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3. Assigned Readings Innate immunity 6-11 Phagocytic deficiences 507-511
Complement
Lysozyme 8, 10
Interferon (INF) , ,
Tumour necrosis factor (TNF)
NK Cells
NK Cells and TNF 391
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4. Content Outline Definitions Exterior Defenses Interior Defenses
Soluble factors
Lysozyme, interferon, complement
Cells
Phagocytes, natural killer cells
Inflammation
chemotaxis, diapedisis, phagocytosis
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5. Innate Immunity: Definition
AKA non adaptive immunity
Non specific
Constant
Those factors that are ALWAYS present to defend the body against infection

6. Adaptive Vs Innate Immunity

7. Defensive Barriers Anatomic Physiologic Phagocytic & Endocytic
Inflammatory
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8. Exterior Defenses

9. Interior Defenses: Soluble Factors
Lysozyme
Interferon
Complement
Cells
Inflammation
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10. Lysozyme

11. Lysozyme Molecule
Lysozyme.pdb

12. Interferon

13. Complement functions

14. Interior Defenses: Cells
Soluble Factors
Cells
Phagocytes
Natural killer cells
Inflammation
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15. Phagocytes: Distribution

16. Monocyte

17. Neutrophil

20. Null Cell

21. Perforin Pores

22. Cytotoxic cell: Pore formation

23. Video of Cytotoxic Lymphocytes
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24. Interior Defenses: Inflammation
Soluble Factors
Cells
Inflammation
Chemotaxis
Diapedesis
Phagocytosis
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25. Monocyte Movement

26. Leucocyte adherance

27. Chemotaxis

28. Diapedesis

29. Macrophage Pseudopodia

30. Neutrophil phagocytosis

31. Phagocytosis

32. Video of Phagocytosis
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33. Summary: Adaptive vs Innate Immunity

34. The End