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T-ALL: Home Is where the CXCL12 Is

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Presentation on theme: "T-ALL: Home Is where the CXCL12 Is"— Presentation transcript:

1 T-ALL: Home Is where the CXCL12 Is
Charles E. de Bock, Jan Cools  Cancer Cell  Volume 27, Issue 6, Pages (June 2015) DOI: /j.ccell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 CXCR4 Surface Expression Is Essential for T-ALL Leukemia Cell Maintenance (A) T-ALL cells (which are CXCR4 positive) are in close contact to vascular cells in the bone marrow that produce CXCL12 (Pitt et al., 2015). (B) CXCR4 cell surface expression is, in part, regulated by cortactin, and the expression of cortactin is dependent on calcineurin (Passaro et al., 2015). Cancer Cell  , DOI: ( /j.ccell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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