1. 6.6: Animals have nervous systems that detect external and internal signals, transmit and integrate information, and produce responses.
1. Neurons

2. All About Neurons
Neurons are highly-specialized cells used by the nervous system to detect signals and transmit them to other neurons or response effectors (muscles or glands)

3. Neuron Anatomy
Allow for electrochemical signals to generated, detected, transmitted and integrated by animals.
Signals move from dendrites to axon to nerve terminals.
Dendrites
Nerve Terminals
Node of Ranvier
Cell Body
Axon
Schwann Cell
Nucleus
Schwann Cell
Nucleus

4. Neuron Diversity
Structure varies depending on role in the nervous system.

6. Action Potentials
At rest, the membrane of a neuron is polarized, with active maintenance of different ion concentrations inside and outside the cell (the “resting potential”).
Na+ is at a higher concentration outside the cell.
K+ is at a higher concentration inside the cell.
An action potential results from the depolarization of a neuronal membrane’s resting potential.

7. When the membrane is depolarized to a “threshold potential”, voltage gated channels in the axon open, and a rapid exchange of ions occurs:

8. Na+ moves in to the cell.
At peak depolarization, K+ ion channels open, K+ ions to move out of the cell.
Na+ channels close, K+ ion channels remain open. K+ continues to move out of the cell, the membrane becomes hyperpolarized.
Na+/K+ pump proteins restore the polarization of the membrane back to the resting potential.
Once the resting potential is restored, the neuron can send another action potential.

9. Action potentials are:
binary (“all or nothing”). There is no gradation to action potentials.

10. Action potentials are:
Self-propagating: Initial depolarization of the membrane triggers the depolarization of the adjacent membrane area.

11. Action potentials are:
Uni-directional: Hyperpolarization following an action potential prevents the action potential from moving backwards.

12. Axon
Image by David S. Goodsell, The Scripps Research Institute. All rights reserved.

13. Myelination greatly increases the speed of action potential transmission, as the signal moves along nodes (“saltatory conduction”).

14. The Myelin Sheath
Axon
Image by David S. Goodsell, The Scripps Research Institute. All rights reserved.

15. Synapses Junctions between neurons.
Signals are transmitted as chemicals (“Neurotransmitters”).

16. Pre-Synaptic Neuron Synaptic Cleft Post-Synaptic Neuron
Image by David S. Goodsell, The Scripps Research Institute. All rights reserved.

17. Different neurotransmitters have different uses.
Ex. Acetylcholine: released by motor neurons at the neuromuscular junction.
Serotonin: Released by neurons in the brain involved in emotional responses.

18. Signal Summation
Incoming signals will be excitatory or inhibitory. The summation of all of the incoming signals will trigger a neuron to send an action potential or not.

19. Integration and Response
Integration: The spatial and temporal pattern of incoming action potentials will be interpreted by the nervous system as a sensation.
Response: the
operation of
muscles, or
the secretion of
hormones are
the major ways
that responses
are effected.

20. The Neuromuscular Junction
Image by David S. Goodsell, The Scripps Research Institute. All rights reserved.

21. 6.6: Animals have nervous systems that detect external and internal signals, transmit and integrate information, and produce responses.
2. Nervous Systems

22. The Taste Game

23. Take one minute to reply to the following prompt:
What is Taste?

24. Let’s Play A Game (With Prizes)
I have these jelly beans
You can do one of two things:
Play
Not Play
If you choose to play: spin the dial, eat the bean, and tell us the taste
If you choose NOT to play: Enjoy the show

25. What about the Prizes!?! For players only:
After playing, you can choose one of two prizes:
A small token of appreciation
The chance to make Ms. Rooney spin the wheel and take her chances.

26. Great work! Now do this (5 minutes):
Why would “good” and “bad” taste evolve?
2. What exactly do we taste when we taste things?
3. Diagram a model showing how taste works from tongue to taste.
4. Design an experiment to investigate a question related to taste using our jelly bean game.

27. Nervous Systems
Animal Nervous Systems have varying levels of complexity.
Evolutionary trends towards centralization and “cephalization” are demonstrated.

28. In Vertebrates, the brain is the central unit for integrating nervous system information and coordinating responses.

29. The brain is part of the central nervous system, which integrates information from the peripheral nervous system.

30. The brain is also the master regulator for the endocrine system.

31. The brain is adapted to maximize connections between neurons.

32. Different regions of the brain have different functions and work together to coordinate the behavior of the organism.
Ex. Medulla/Cerebellum/Cerebrum

33. Ex. Right hemisphere/left hemisphere separation.

34. Ex. Vision and Hearing Centers

35. Ex. Cerebrum Functions

36. The effect of drugs on the nervous system

37. Image Credits
All images taken from wikimedia commons and OpenStax College. Biology, Connexions Web site. May 30, 2013.
Exceptions: Slide 22-
Images by David S. Goodsell, the Scripps Research Institute where indicated.